Abstract
The aim of this study is to investigate the use of two freely available Monte Carlo (MC) codes to model simple geometrical radionuclide configurations, which could be compared to experimental measurements or analytical calculus for internal dosimetry. Three spherical geometries were simulated using GATE 7.1 and PENELOPE 2008: (1) a point source centered in a 10 cm radius sphere; (2) a 5 cm radius sphere with homogeneous radioactive distribution inside a 10 cm radius sphere; (3) two separated spheres (5 and 10 cm radius) 5 cm apart, the first acting as source and the second as target. All spheres were filled with water and sources produced 108 primary gamma emissions from 99mTc. Total absorbed doses were analyzed using 3D Dose Point Kernel (DPK). Results obtained with GATE and PENELOPE simulations were, respectively: (1) 15 and 14.25 mGy, with 5.2% difference; (2) 7.4 and 8.51 mGy, showing higher difference (13.04%); (3) 0.93 and 0.97 mGy, in target sphere. Concluding, GATE and PENELOPE MC codes can be easily used to simulate simple geometries, allowing for comparison against experimental measurements or analytical calculations. Further studies are required to compare these simulation results with experimental data designed to the clinical practice.
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References
Committee on Medical Internal Radiation Dose (MIRD) Homepage, http://www.snmmi.org/ClinicalPractice/content.aspx?ItemNumber=4212, last accessed 2017/01/24.
Stabin, M., Sparks, R.: Crowe, E.: OLINDA/EXM: The Second-Generation Personal Computer Software for Internal Dose Assessment in Nuclear Medicine. J Nucl Med (48), 1023–1027 (2005).
Zaidi, H., Sgouros, G.: Therapeutic Applications of Monte Carlo Calculations in Nuclear Medicine. 1st ed Institute of Physics Publishing, London (2003).
Stabin, M.: Uncertainties in Internal Dose Calculations for Radiopharmaceuticals. J Nucl Med (49), 853–860 (2008).
Allison, J. et al.: Recent developments in Geant4. Nuclear Instruments and Methods A 835, 186–225 (2016).
Salvat, F., Fernández-Varea: J. M.: Penelope-2008: A code system for Monte Carlo simulation of electron and photon transport. Nuclear Energy Agency, (2008).
Flux, G., Bardies, M., Monsieurs, M., Savolainen, S., Strand, S., Lassmann, M.: The Impact of PET and SPECT on Dosimetry for Targeted Radionuclide Therapy. Med Phys (16) 1, 47–59 (2006).
Papadimitroulas, P., Loudos, G. et al. Photon dose kernels dataset for nuclear medicine dosimetry, using the GATE Monte Carlo toolkit. Med Phys 39 (8):5238–5247 (2012).
Falzone, N. Fernández-Varea, J.M., Flux, G. and Vallis, K.A. Monte Carlo Evaluation of Auger Electron–Emitting Theranostic Radionuclides. J Nucl Med, 56 (9):1441–1446 (2015).
Zanotti-Fregonara, P. et al. New Fetal Dose Estimates from 18F-FDG Administered During Pregnancy: Standardization of Dose Calculations and Estimations with Voxel-Based Anthropomorphic Phantoms. J Nucl Med 57 (11):1760–1763 (2016).
Dartora, C.M., Cavedini, N.G., and Marques da Silva, A.M.: Comparison between fetal dose estimates for [18F] FDG PET imaging in pregnant patient using static and dynamic bladder voiding models. In: 30th Annual Congress of the European Association of Nuclear Medicine, 2017, Viena. EJNMMI, Berlin: Springer Berlin, 2017. v. 44. p. S290–S291.
Sarrut, D., Bardiès, M., Boussion, N.: A review of the use and potential of the GATE Monte Carlo simulation code for radiation therapy and dosimetry applications. Med Phys (41) 6: 064301 (2014).
Tagesson, M., Ljungberg, M., Strand, S.: A Monte Carlo Program Converting Activity Distributions to Absorbed Dose Distributions in a Radionuclide Treatment Planning System. Acta Oncologica (35) 3, 367–372 (1996).
Furhang, Eli., Sgouros, G., Chui, Chen-Shou.: Radionuclide photon dose kernels for internal emitter dosimetry. Med Phys (23) 5, 759–764 (1996).
GEANT4 Homepage, http://geant4.web.cern.ch/geant4/UserDocumentation/UsersGuides/PhysicsReferenceManual/BackupVersions/V10.1/fo/PhysicsReferenceManual.pdf, last accessed 2018/01/24.
Prestwich, W.V., Nunes, J. and Kwok, C.S.: Beta dose point kernels for radionuclides of potential use in radioimmunotherapy. J Nucl Med 30:1036–1046 (1989).
Loevinger, R. and Berman, M.: A formalism for calculation of absorbed dose from radionuclides. Physics in Medicine and Biology 13 (2), 205–217 (1968).
Zanotti-Fregonara, P. and Stabin, M.G.: New Fetal Radiation Doses for 18F-FDG Based on Human Data. J Nucl Med 58:1865–1866 (2017).
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Cavedini, N.G., Dartora, C.M., de Moura, L.V., Schwarcke, M.M.B., Marques da Silva, A.M. (2019). Radionuclide Internal Dosimetry Using GATE and PENELOPE for Experimental Validation in Geometrical Phantoms. In: Lhotska, L., Sukupova, L., Lacković, I., Ibbott, G.S. (eds) World Congress on Medical Physics and Biomedical Engineering 2018. IFMBE Proceedings, vol 68/1. Springer, Singapore. https://doi.org/10.1007/978-981-10-9035-6_135
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