Abstract
The emergence of antibiotic resistant pathogenic strains is well documented and currently available drugs are becoming less effective in combating infections. In addition, pathogens often form biofilms as a survival strategy. This phenomenon is significant in aquaculture, industrial and environmental settings as well. In most pathogens, quorum sensing plays an important role in survival; development of virulence factors and in pathogenicity. An understanding of the molecular basis of this phenomenon has led to the development of new strategies for disease control and a search for molecules interfering with related processes. Marine environments are hotspots for biodiversity and various quorum sensing inhibitors (QSIs) have been reported from this habitat. This chapter describes the salient features of biosensor strains used for screening QSIs from the marine environment and details chemical structures of inhibitors derived from different marine organisms (bacteria, fungi, algae and invertebrates) in a classified manner. Different biotechnological applications of QSIs as antivirulence drugs, antibiofilm agents, antifouling compounds and their use in aquaculture practices have also been highlighted. QSIs may in the future may, to some extent, be useful as replacements for antibiotics.
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Hamza, F., Zinjarde, S. (2018). Marine Biodiversity As a Resource for Bioactive Molecules As Inhibitors of Microbial Quorum Sensing Phenotypes. In: Kalia, V. (eds) Biotechnological Applications of Quorum Sensing Inhibitors. Springer, Singapore. https://doi.org/10.1007/978-981-10-9026-4_16
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