Radiotherapy Dose Measurements Using a Fluorescing Quinine Solution

  • Scott CroweEmail author
  • Steven Sylvander
  • Tanya Kairn
Conference paper
Part of the IFMBE Proceedings book series (IFMBE, volume 68/3)


Quinine solutions fluoresce when exposed to ionising radiation, through the production and absorption of Čerenkov radiation. This study evaluated the feasibility of using ‘household’ tonic water as a radiotherapy dosimeter. Tonic water samples were irradiated with static beams for a variety of energies and dose rates: 6 and 10 MV photons at 600 MU/min; 6 MV flattening-filter-free photons at 1400 MU/min; 6, 9, 12, 15 and 18 meV electrons at 400 MU/min and 6 meV electrons at approximately 2474 MU/min (used for total skin electron irradiation). A sliding window IMRT field was delivered using a 6 MV photon beam at 600 MU/min, to assess dynamic response. Fluorescence was successfully recorded using a monochrome low light CCD camera placed on the treatment couch as well as the treatment room visual monitoring system in the linear accelerator control area. Energy dependence and dose rate independence were observed. While limitations in the bit-depth and focal length of the camera prevented precise quantitative analysis of depth dose profiles for conventional dose rates (≤600 MU/min), performance for higher dose rates (in terms of signal-to-noise in depth dose profiles) was comparable to radiochromic film. Potential use includes measurement of dose in the build-up region, efficient checks of beam energy and tomographic reconstruction of 4D dose delivery, though further optimisation of fluorescent signal acquisition is required.


Radiation therapy Dosimetry Fluorescence 


Compliance with Ethical Standards

The authors declare that they have no conflict of interest. This article does not contain any studies with human participants or animals performed by any of the authors.


  1. 1.
    Pönisch, F., Archambault, L., Briere, T.M., et al.: Liquid scintillator for 2D dosimetry for high-energy photon beams. Med. Phys. 36(5), 1478–1485 (2009).
  2. 2.
    Goulet, M., Rilling, M., Gingras, L., et al.: Novel, full 3D scintillation dosimetry using a static plenoptic camera. Med. Phys. 41(8), 082101 (2014).
  3. 3.
    Glaser, A.K., Davis, S.C., Voigt, W.H.A., et al.: Projection imaging of photon beams using Čerenkov-excited fluorescence. Phys. Med. Biol. 58(3), 601–609 (2013).
  4. 4.
    Glaser, A.K., Andreozzi, J.M., Davis, S.C., et al.: Video-rate optical dosimetry and dynamic visualization of IMRT and VMAT treatment plans in water using Cherenkov radiation. Med. Phys. 41(6), 062102 (2014).
  5. 5.
    Pogue, B.W., Glaser, A.K., Zhang, R., Gladstone, D.J.: Cherenkov radiation dosimetry in water tanks video rate imaging, tomography and IMRT & VMAT plan verification. J. Phys. Conf. Ser. 573, 012013 (2015)
  6. 6.
    Bruza, P., Andreozzi, J.M., Gladstone, D.J., et al.: Real-time 3D dose imaging in water phantoms: reconstruction from simultaneous EPID-Cherenkov 3D imaging (EC3D). J. Phys. Conf. Ser. 847, 012034 (2017).
  7. 7.
    Pogue, B.W., Zhang, R., Glaser, A., et al.: Cherenkov imaging in the potential roles of radiotherapy QA and delivery. J. Phys. Conf. Ser. 847, 012046 (2017).
  8. 8.
    Andreozzi, J.M., Zhang, R., Glaser, A. K., et al.: Camera selection for real-time in vivo radiation treatment verification systems using Cherenkov imaging. Med. Phys. 42(2), 994–1004 (2015).
  9. 9.
    Andreozzi, J.M., Zhang, R., Gladstone, D.J., et al.: Cherenkov imaging method for rapid optimization of clinical treatment geometry in total skin electron beam therapy. Med. Phys. 43(2), 993–1002 (2016).
  10. 10.
    Streller, S., Roth, K.: Eine Rinde erobert die Welt: Von der Apotheke an die Bar. Chemie. in. unserer. Zeit. 46(4), 228–247 (2012).
  11. 11.
    Fitchew, R.S., Nitschke, K.N., Christiansen, P.G.: Total skin electron beam therapy using a Dynaray 18 linear accelerator. Australas. Phys. Eng. Sci. Med. 8(4), 182–187 (1985).Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Royal Brisbane and Women’s HospitalBrisbaneAustralia
  2. 2.Queensland University of TechnologyBrisbaneAustralia

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