Abstract
To evaluate systemic circulatory support devices such as left ventricular assist system, surgical heart valve prosthesis, and transcatheter aortic valve, various in vitro hydrodynamic tests have been performed. As these devices are being applied to the pulmonary circulatory support in recent years, novel evaluation platform for right heart support is increasingly demanded. This study aims to develop a pulmonary mechanical circulatory simulation system to assess the hydrodynamic performance of newly designed artificial cardiovascular devices. For the construction of the system, we developed the pneumatically-driven polymer right atrial and ventricular models with the pulmonary arterial valve chamber, silicone-made peripheral pulmonary artery model, and a venous reservoir. A woven polyester vascular graft and commercially available mechanical bileaflet valve were installed into the valve chamber. Then, the right ventricular pressure and pulmonary arterial pressure were regulated by the peripheral resistive unit. As a result, we successfully obtained the standard conditions of our mechanical circulatory system to be 28/3 (systolic/diastolic) mmHg of right ventricular pressure, 29/7 mmHg of pulmonary arterial pressure, 6 mmHg of mean right atrial pressure, and 3.0 L/min of pulmonary flow rate. To carry out the sophisticated assessment for the support of the pulmonary surgical and percutaneous treatments, we are preparing the next step with the reproduction of respiratory changes in pulmonary peripheral resistance, and the patient-specific shape vascular model including catheter access vessels. Under the highly simulated both pulmonary anatomical morphology and hemodynamic function conditions, effective preclinical examination of newly designed surgical or percutaneous pulmonary circulatory support devices can be performed.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Smith, J.J., Kampine, J.P.: Circulatory Physiology: The Essentials. 2nd Japanese edn. Igaku-Shoin, Tokyo (1989).
Suzuki, I., Shiraishi, Y., Yabe, S., Tsuboko, Y., Sugai, T.K., Matsue, K., Kameyama, T., Saijo, Y., Tanaka, T., Okamoto, Y., Feng, Z., Miyazaki, T., Yamagishi, M., Yoshizawa, M., Umezu, M., Yambe, T.: Engineering analysis of the effects of bulging sinuses in a newly designed pediatric pulmonary heart valve on hemodynamic function. Journal of Artificial Organs 15(1), 49–56 (2012).
Tsuboko, T., Shiraishi, Y., Matsuo, S., Yamada, A., Miura, H., Shiga, T., Hashem, M.O., Yambe, T.: Effect of right atrial contraction on prosthetic valve function in a mechanical pulmonary circulatory system. Journal of Biomechanical Science and Engineering 11(6) 15-00356 (2016).
Badesch, D.B., Champion, H.C., Sanchez, M.A.G., Hoeper, M.M., Loyd, J.E., Manes, A., McGoon, M., Naeije, R., Olschewski, H., Oudiz, R.J., Torbicki, A.: Diagnosis and assessment of pulmonary arterial hypertension. Journal of American College of Cardiology 54(1), 55–66 (2009).
Nichols, W.W., O’Rourke, M.F., Vlachopoulos, C.: McDonald’s Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles. 6th edn. CRC Press, Boca Raton/FL (2011).
Murgo, J.P. and Westerhof, N.: Input impedance of the pulmonary arterial system in normal man. Effect of respiration and comparison to systemic impedance. Circulation. 54, 666–73 (1984).
Lucas, C.L., Radke, N.F., Wilcox, B.R., Henry, G.W., Keagy B.A.: Maturation of Pulmonary Input Impedance Spectrum in Infants and Children with Ventricular Septal Defect. American Journal of Cardiology 57, 821–827 (1986).
Weinberg, C.E., Hertzberg, J.R., Ivy, D.D., Kirby, K.S., Chan, K.C., Valdes-Cruz, L., Shandas, R.: Extraction of Pulmonary Vascular Compliance, Pulmonary Vascular Resistance, and Right Ventricular Work from Single-Pressure and Doppler Flow Measurements in Children with Pulmonary Hypertension: a New Method for Evaluating Reactivity. Circulation 110, 2609–2617 (2004).
Hunter, K.S., Lee, P.F., Lanning, C.J., Ivy, D.D., Kirby, K.S., Claussen, L.R., Chan, K.C., Shandas, R.: Pulmonary vascular input impedance is a combined measure of pulmonary vascular resistance and stiffness and predicts clinical outcomes better than pulmonary vascular resistance alone in pediatric patients with pulmonary hypertension. American Heart Journal 155(1), 166–174 (2008).
Acknowledgements
This work was partly supported by the Cooperative Research Project Program of Joint Usage/Research Center at the Institute of Development, Aging and Cancer, Tohoku University.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Ethics declarations
The authors have no relationships that could be construed as a conflict of interest.
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this paper
Cite this paper
Tsuboko, Y., Shiraishi, Y., Yamada, A., Iwasaki, K., Umezu, M., Yambe, T. (2019). Sophisticated Hydrodynamic Simulation of Pulmonary Circulation for the Preclinical Examination of Right Heart Circulatory Assist Device. In: Lhotska, L., Sukupova, L., Lacković, I., Ibbott, G. (eds) World Congress on Medical Physics and Biomedical Engineering 2018. IFMBE Proceedings, vol 68/3. Springer, Singapore. https://doi.org/10.1007/978-981-10-9023-3_130
Download citation
DOI: https://doi.org/10.1007/978-981-10-9023-3_130
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-9022-6
Online ISBN: 978-981-10-9023-3
eBook Packages: EngineeringEngineering (R0)