Abstract
Horses, buffaloes, and pigs have been reported to be prion resistant species with naturally low susceptibility to prion diseases. The β2-α2 loop is well-structured in the NMR structure of horse prion protein. Pig prion protein has a NMR structure released into PDB Bank in early 2005. Water buffaloes have no structure found yet but we had made a homology structure by ourselves (J Biomol Struct Dyn 34(4):762–777, 2016). In this chapter, we will do MD studies on all these molecular structures of horse, buffalo and pig prion proteins, in order to reveal some secrets of their resistance to prion diseases.
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References
Zhang JP (2011b) The structural stability of wild-type horse prion protein. J Biomol Struct Dyn 29(2):369–377
Zhang JP, Chatterjee S, Wang F (2017) Using graph theory and optimization theory to do data mining the large scale buffalo prion protein structure database. Oper Res Trans 21(2):73–83
Zhang JP, Wang F, Chatterjee S (2016) Molecular dynamics studies on the buffalo prion protein. J Biomol Struct Dyn 34(4):762–777
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Zhang, J. (2018). Horses, Buffaloes, and Pigs. In: Molecular Dynamics Analyses of Prion Protein Structures. Focus on Structural Biology, vol 10. Springer, Singapore. https://doi.org/10.1007/978-981-10-8815-5_4
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DOI: https://doi.org/10.1007/978-981-10-8815-5_4
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Online ISBN: 978-981-10-8815-5
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