Anti-epileptic Action of Thymoquinone
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A number of studies have been carried out to establish the anti-epileptic activity of N. sativa. Thymoquinone (TQ) is found in volatile oil of the plant and is considered the main constituent responsible for its anti-epileptic effect. Mechanism of action of TQ on seizures is not completely established; however some researchers believe that it produces anticonvulsant effect by interacting with gamma-aminobutyric acid (GABA). Some researchers in their study found that the co-administration of TQ and some known anti-epileptic drugs led to the potentiation of their anti-epileptic effect and suppressed their adverse effects.
KeywordsThymoquinone (TQ) Anticonvulsant Activity Anticonvulsant Effects Calmodulin-dependent Protein Kinase II (CaMKII) International League Against Epilepsy (ILAE)
- Hosseinzadeh H, Parvardeh S, Nassiri-Asl M et al (2005) Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. Med Sci Monit 11(4):BR106–BR110Google Scholar