Pharmacogenetic Study in Asthma

  • Quan-Jun Yang
  • Cheng Guo
Part of the Translational Bioinformatics book series (TRBIO, volume 12)


Asthma could be viewed as a complex multifactor genetic disease associated with multiple genes. For clinical asthma patients with similar phenotypes, the same treatment can cause very different reactions. Many studies strongly suggest that genetic factors significantly contribute to the clinical outcomes of interindividual pharmacological treatment. To reveal the genetic differences in drug response and drug behavior, pharmacogenomics was developed and expanded to explain the response of drug treatment with acquisition and inheritance factors through the systematic examination of individual variability gene. The pharmacogenetics goal of asthma is to personalize asthma pharmacotherapy and reduce the asthma burden. The present manuscript discusses the coding sequences or regulatory regions of genes that encode proteins involved in asthma pharmacological responses.


Asthma Pharmacogenomics Glucocorticoid β2-adrenergic receptor 



Cyclic adenosine monophosphate


Forced expiratory volume within 1 s




Long acting β2-agonist


Short acting β2-agonist


Single nucleotide polymorphism


Ultra long acting beta2-agonist


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of PharmacyShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghaiChina

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