Abstract
Recurrent miscarriage (RM) remains unexplained in >50% of patients and causes both physical and psychological burdens in women without specific risk factors for miscarriage. Unexplained RM is defined as a failure to achieve delivery owing to chance or undetectable causes of pregnancy loss, including unbalanced maternal immune tolerance, impaired intrauterine circumstances, and perturbation of decidualized endometrium. In 60–70% of patients with a history of three to four miscarriages, delivery is achieved without any treatment, whereas the miscarriage rate in patients with five or more pregnancy losses is >50%, of which ≥60% are losses of fetuses with normal embryonic karyotypes. Thus, the rate of miscarriage and the number of losses of fetuses with normal embryonic karyotype increase with an increase in the number of pregnancy losses, suggesting that maternal, not fetal, risk factors are present in patients with a history of multiple pregnancy losses. However, 75% of patients with unexplained RM achieve delivery after an appropriate treatment.
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Kuroda, K. (2018). Unexplained Recurrent Miscarriage: Introduction. In: Kuroda, K., Brosens, J., Quenby, S., Takeda, S. (eds) Treatment Strategy for Unexplained Infertility and Recurrent Miscarriage. Springer, Singapore. https://doi.org/10.1007/978-981-10-8690-8_7
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DOI: https://doi.org/10.1007/978-981-10-8690-8_7
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