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Treatment Strategy for Unexplained Recurrent Miscarriage

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Treatment Strategy for Unexplained Infertility and Recurrent Miscarriage

Abstract

Couples with unexplained recurrent miscarriage (RM) cannot achieve live birth, because of repeated sporadic abortion or undetected causes of RM on common examinations. The undetected causes of RM include complexed multiple risk factors of pregnancy loss as multifactorial disease and perturbation of endometrial decidualization. To avoid subsequent pregnancy loss, recommendations for RM treatment include modification of lifestyle habits to eliminate risk factors of miscarriage; vitamin D supplementation, if deficient; adequate diagnosis and treatment of chronic endometritis; and oral dydrogesterone treatment as a part of “tender loving care.” If patients have diminished ovarian reserves or are >40 years old, infertility treatment should be recommended. If subsequent pregnancy ends in miscarriage, chromosome analysis of chorionic villi samplings is required for planning treatment strategy of the subsequent pregnancy. If the result is euploid, further investigations for the cause of RM and reexamination of treatment strategy are required.

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Author information

Authors and Affiliations

  1. Center for Reproductive Medicine and Implantation Research, Sugiyama Clinic Shinjuku, Tokyo, Japan

    Keiji Kuroda

  2. Department of Obstetrics and Gynaecology, Faculty of Medicine, Juntendo University, Tokyo, Japan

    Keiji Kuroda

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  1. Keiji Kuroda
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Correspondence to Keiji Kuroda .

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Editors and Affiliations

  1. Center for Reproductive Medicine and Implantation Research, Sugiyama Clinic Shinjuku, Tokyo, Japan

    Keiji Kuroda

  2. Department of Obstetrics and Gynaecology, Faculty of Medicine, Juntendo University, Tokyo, Japan

    Jan J. Brosens

  3. The Division of Biomedical Sciences, Clinical Science Research Laboratories Warwick Medical School, Coventry, United Kingdom

    Siobhan Quenby

  4. Department of Obstetrics and Gynaecology, Juntendo University, Tokyo, Japan

    Satoru Takeda

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Kuroda, K. (2018). Treatment Strategy for Unexplained Recurrent Miscarriage. In: Kuroda, K., Brosens, J., Quenby, S., Takeda, S. (eds) Treatment Strategy for Unexplained Infertility and Recurrent Miscarriage. Springer, Singapore. https://doi.org/10.1007/978-981-10-8690-8_11

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  • DOI: https://doi.org/10.1007/978-981-10-8690-8_11

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  • Online ISBN: 978-981-10-8690-8

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