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Obesity, Fatty Liver and Liver Cancer pp 111–125Cite as

Microbiota, Obesity and NAFLD

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 1061)

Abstract

Non-alcoholic fatty liver disease (NAFLD) is an increasingly important cause of chronic liver disease globally. Similar to metabolic syndrome and obesity, NAFLD is associated with alternations in the gut microbiota and its related biological pathways. While the exact pathophysiology of NAFLD remains largely unknown, changes in intestinal inflammation, gut permeability, energy harvest, anaerobic fermentation and insulin resistance have been described. In this chapter, we review the relationship between the gut microbiota, obesity and NAFLD, and highlight potential ways to modify the gut microbiota to help managing NAFLD patients.

Keywords

  • Fatty liver
  • Microbiota
  • Intestinal inflammation
  • Gut permeability
  • Energy harvest
  • Insulin resistance

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Fig. 9.1
Fig. 9.2

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  1. Institute of Digestive Disease, State Key Laboratory of Digestive Diseases, Department of Medicine & Therapeutics and LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    Louis H. S. Lau & Sunny H. Wong

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    Jun Yu

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Lau, L.H.S., Wong, S.H. (2018). Microbiota, Obesity and NAFLD. In: Yu, J. (eds) Obesity, Fatty Liver and Liver Cancer. Advances in Experimental Medicine and Biology, vol 1061. Springer, Singapore. https://doi.org/10.1007/978-981-10-8684-7_9

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