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Epidemiology and Etiologic Associations of Non-alcoholic Fatty Liver Disease and Associated HCC

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Obesity, Fatty Liver and Liver Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1061))

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world and will soon become the number one cause of hepatocellular carcinoma (HCC), liver transplantation and liver-related mortality. The disease often occurs in the setting of metabolic conditions such as obesity and type II diabetes mellitus. These same metabolic drivers are also risk factors for NAFLD associated HCC which can occur even in the absence of cirrhosis or advanced fibrosis and appears to be phenotypically different to HCCs arising from other chronic liver diseases. The frequencies of liver-related events and HCC among NAFLD patients is low, especially when compared to cardiovascular disease and extrahepatic malignancies. However, the large denominator of total patients affected with NAFLD means that these events will impose an enormous clinical and economic burden on our society. Moreover, this burden is expected to rise further in the future. Therefore, the global NAFLD epidemic has arrived at our doorstep and demands our attention.

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Authors and Affiliations

  1. AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Sydney, NSW, Australia

    Ken Liu & Geoffrey W. McCaughan

  2. Faculty of Medicine, University of Sydney, Sydney, NSW, Australia

    Ken Liu & Geoffrey W. McCaughan

  3. Centenary Institute, University of Sydney, Sydney, NSW, Australia

    Ken Liu & Geoffrey W. McCaughan

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  1. Ken Liu
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  2. Geoffrey W. McCaughan
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Correspondence to Geoffrey W. McCaughan .

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  1. Institute of Digestive Disease and Department of Medicine & Therapeutics State Key Laboratory of Digestive Disease LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    Jun Yu

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Liu, K., McCaughan, G.W. (2018). Epidemiology and Etiologic Associations of Non-alcoholic Fatty Liver Disease and Associated HCC. In: Yu, J. (eds) Obesity, Fatty Liver and Liver Cancer. Advances in Experimental Medicine and Biology, vol 1061. Springer, Singapore. https://doi.org/10.1007/978-981-10-8684-7_2

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