Harnessing Chemoselective Imine Ligation for Tethering Bioactive Molecules to Platinum(IV) Prodrugs

  • Daniel Yuan Qiang WongEmail author
Part of the Springer Theses book series (Springer Theses)


Platinum(II)-based drugs, namely cisplatin, carboplatin and oxaliplatin, are the first line of treatment for many types of malignancies, including testicular, ovarian and lung cancer (Kelland in Nat Rev Cancer 7:573–584, [1]; Abu-Surrah and Kettunen in Curr Med Chem 13:1337–1357, [2]). However, their efficacy is severely limited by adverse side-effects due to high toxicities and incidences of drug resistance, either inherent or acquired (Fuertes et al. in Chem Rev 103:645–662, [3]).


Platinum Imine Proton NH4OAc Buffer Crude Reaction Mixture Oxime Bond Formation 
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Supplementary material


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of ChemistryNational University of SingaporeSingaporeSingapore

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