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Elucidation of Mechanisms of Anticancer Plant Compounds Against the Tumor Cells

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Anticancer Plants: Mechanisms and Molecular Interactions

Abstract

Cancer is one of the noncommunicable diseases which is the second leading cause of deaths throughout the world. Chemotherapy is the major treatment approach, however, with a limited success rate accompanied by secondary adverse health effects. Moreover, in recent years, about 30–80% of cancer patients are developing resistance to chemotherapeutic drugs. Therefore, phytoconstituents have attained much attention among the researchers because of their effective multiple targeted cytotoxicity with a tolerable side effects and chemosensitizing potential. These are known to exhibit their anticancer activities in various ways of molecular mechanisms of action, such as arresting of cell cycle, inhibiting angiogenesis, inhibiting enzymes (cyclooxygenase, caspases, kinase matrix metalloproteinase (MMP), poly(ADP-ribose) polymerase 1 (PARP-1), etc.), inhibiting transcription factors, suppressing pro-inflammatory signaling pathways, inhibiting lipid signals, and inhibiting heat shock proteins. Though scientific evidences have suggested many plant compounds with chemopreventive potential, understanding the issues related to exposure time, bioavailability, toxic effects, and mechanisms of action will certainly help to identify the leads and utilize them against various cancer types. The present chapter deals with the anticancer effect of several compounds of plant origin and their mechanisms of action.

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Authors and Affiliations

  1. Bio Incubator and Lab, Vel Tech Technology Incubator, Vel Tech Rangarajan Dr. Sagunthala R & D Institute of Science and Technology, Chennai, Tamil Nadu, India

    Radhakrishnan Narayanaswamy

  2. Department of Crop Science, Faculty of Agriculture, Universiti Putra Malaysia (UPM), Serdang, Selangor, Malaysia

    Mallappa Kumara Swamy

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  1. Radhakrishnan Narayanaswamy
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  2. Mallappa Kumara Swamy
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Correspondence to Radhakrishnan Narayanaswamy .

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  1. Department of Botany, Gandhi Faiz-e-Aam College, Shahjahanpur, Uttar Pradesh, India

    Mohd Sayeed Akhtar

  2. Department of Crop Science,Faculty of Agriculture, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

    Mallappa Kumara Swamy

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Narayanaswamy, R., Swamy, M.K. (2018). Elucidation of Mechanisms of Anticancer Plant Compounds Against the Tumor Cells. In: Akhtar, M., Swamy, M. (eds) Anticancer Plants: Mechanisms and Molecular Interactions. Springer, Singapore. https://doi.org/10.1007/978-981-10-8417-1_4

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