Medical Radiation Countermeasures for Neuroprotection: Herbal Solutions, Evidences, and Challenges Therein

  • Madhu Bala
  • Vanita Gupta
Chapter

Abstract

Neurotoxicity, nausea, vomiting, and behavioral alterations are severe side effects experienced by patients undergoing brain tumor radiotherapy, which arise due to radiation toxicity to the normal cells. Development of prophylactic drugs for countering radiation toxicity remains an unmet demand till date, world over. Incomplete understanding of complex mechanisms of radiation neurotoxicity is an essential limiting factor. Thousands of single molecule drugs failed due to their toxic effects, but plant extracts were found to be more efficacious with almost negligible toxicity. Significant radioprotective properties of a specific patented preparation (coded as SBL-1) from leaves of sea buckthorn [Hippophae rhamnoides L. (Elaeagnaceae)] were reported. A single dose of SBL-1, administered 30 min before total body 60Cobalt-gamma-irradiation (lethal dose 10 Gray), rendered survival of more than 90% mice population against zero survival in non-SBL-1 treated animals. This communication briefly summarizes the recent progress made in understanding the effects of SBL-1 on radiation-induced neuroprotection in rats at the therapeutic radiation dose (2Gray) and also the scope of developing SBL-1 as radiation countermeasure for human use.

Notes

Acknowledgment

This study was supported by the Government of India, Ministry of Defence, Defence Research and Development Organization under project INM-311/1.2/ST-P1-2009. The support provided by DIHAR, Leh, in collection of plant material is gratefully acknowledged.

References

  1. Bala M, Saini M (2013) Validated HPTLC methods for quantification of marker compounds in aqueous extract of Hippophae rhamnoides leaves. Int J Pharm Sci Rev Res 23(2):58–63Google Scholar
  2. Bala M, Prasad J, Singh S, Tiwari S, Sawhney RC (2009) Whole body radioprotective effects of SBL-1: a preparation from leaves of Hippophae rhamnoides. J Herbs Spices Med Plants 15:203–215CrossRefGoogle Scholar
  3. Bala M, Gupta M, Saini M, Abdin MZ, Prasad J (2015) Sea buckthorn leaf extract protects jejunum and bone marrow of 60cobalt-gamma-irradiated mice by regulating apoptosis and tissue regeneration. Evid Based Complement Alternat Med 2015:1–10, Article ID 765705CrossRefGoogle Scholar
  4. Cairnie AB (1983) Adverse effects of the radioprotector WR-2721. Radiat Res 94:221–226CrossRefGoogle Scholar
  5. Cairnie AB, Leach KE (1982) Dexamethasone: a potent blocker for radiation-induced taste aversion in rats. Pharmacol Biochem Behav 17:305–311CrossRefGoogle Scholar
  6. Czerwinski AW, Czerwinski AB, Clark ML, Whitsett TL (1972) A double blind comparison of placebo and WR-2721 AE in normal adult volunteers, Washington DC, US Army Medical Research and Development Command, report no. MCA 1-33Google Scholar
  7. Faria A, Pestana D, Teixeira D, Couraud PO, Romero I, Weksler B, de Freitas V, Mateus N, Calhau C (2011) Insights into the putative catechin and epicatechin transport across blood-brain barrier. Food Funct 2:39–44CrossRefGoogle Scholar
  8. Guan TTY, Cenkowski S, Hydamaka A (2005) Effect of drying on the nutraceutical quality of sea buckthorn (Hippophae rhamnoides L. ssp. sinensis) leaves. J Food Sci 70:E514–E518CrossRefGoogle Scholar
  9. Gupta V, Bala M, Prasad J, Singh S, Gupta M (2011) Leaves of Hippophae rhamnoides prevent taste aversion in gamma-irradiated rats. J Diet Suppl 8:355–368CrossRefGoogle Scholar
  10. Gόrnaś P, Šnē E, Siger A, Seglina D (2014) Sea buckthorn (Hippophae rhamnoides L.) leaves as valuable source of lipophilic antioxidants: the effect of harvest time, sex, drying and extraction methods. Ind Crop Prod 60:1–7CrossRefGoogle Scholar
  11. Gόrnaś P, Šnē E, Siger A, Seglina D (2016) Sea buckthorn (Hippophae rhamnoides L.) vegetative parts as an unconventional source of lipophilic antioxidants. Saudi J Biol Sci 23:512–516CrossRefGoogle Scholar
  12. Haque AM, Hashimoto M, Katakura M, Tanabe Y, Hara Y, Shido O (2006) Long-term administration of green tea catechins improves spatial cognition learning ability in rats. J Nutr 136:1043–1047CrossRefGoogle Scholar
  13. Kumar MSY, Dutta R, Prasad D, Misra K (2011) Subcritical water extraction of antioxidant compounds from Sea buckthorn (Hippophae rhamnoides) leaves for the comparative evaluation of antioxidant activity. Food Chem 127:1309–1316CrossRefGoogle Scholar
  14. Saini M, Tiwari S, Prasad J, Singh S, Kumar MSY, Bala M (2010) Hippophae leaf extract concentration regulates antioxidant and pro-oxidant effects on DNA. J Diet Suppl 7:60–70CrossRefGoogle Scholar
  15. Saini M, Bala M, Farooqi H, Abdin MZ, Prasad J (2014) Renoprotective activity of Hippophae leaf extract in total body 60Co-gamma-irradiated mice: an oxidative and histopathology study. Int J Pharm Pharm Sci 6(3):161–166Google Scholar
  16. Scarantino CW, Ornitz RD, Hoffman LG, Anderson RF Jr (1994) On the mechanism of radiation induced emesis: the role of serotonin. Int J Radiat Oncol Biol Phys 30(4):825–830CrossRefGoogle Scholar
  17. Schroeter H, Bahia P, Spencer JP, Sheppard O, Rattray M, Cadenas E, Rice-Evans C, Williams RJ (2007) Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons. J Neurochem 101:1596–1606CrossRefGoogle Scholar
  18. Scott TR (2011) Learning through the taste system. Front Syst Neurosci 5:1–6CrossRefGoogle Scholar
  19. Sen S, Chakraborty R (2011) The role of antioxidants in human health. In: Andreescu S, Hepel M (eds) Oxidative stress: diagnostics, prevention, and therapy. American Chemical Society, Washington, DC, pp 1–37Google Scholar
  20. Smith JC (1971) Radiation: its detection and its effect on taste preferences. In: Stellar E, Sprague JM (eds) Progress in physiological psychology. Academic Press, New York, pp 53–118Google Scholar
  21. Tiwari S, Bala M (2011) Hippophae leaves prevent immunosuppression and inflammation in 60Co-γ-irradiated mice. Phytopharmacology 1:36–48Google Scholar
  22. Tiwari S, Arya A, Tyagi S, Prasad J, Singh S, Vats P, Kumar D, Jain SK, Bala M (2009) Anti-oxidative, anti-mutagenic and radioprotective properties of sea buckthorn leaf (Hippophae rhamnoides L.) Zeitschrift fur Arznei- and Gewurzpflanzen 14:83–89Google Scholar
  23. Welzl H, D’Adamo P, Lipp HP (2001) Conditioned taste aversion as a learning and memory paradigm. Behav Brain Res 125:205–213CrossRefGoogle Scholar
  24. Youdim KA, Qaiser MZ, Begley DJ, Rice-Evans CA, Abbott NJ (2004) Flavonoid permeability across an in situ model of the blood-brain barrier. Free Radic Biol Med 36:592–604CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Madhu Bala
    • 1
    • 2
  • Vanita Gupta
    • 1
  1. 1.Radiation Biology DivisionInstitute of Nuclear Medicine and Allied SciencesNew DelhiIndia
  2. 2.Defence Institute of Bio-Energy Research, Defence Research and Development OrganizationMinistry of DefenceNew DelhiIndia

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