Analysis of Cerebrospinal Fluid for Proteins and Sugars

  • Vijay Kumar
  • Kiran Dip Gill


Cerebrospinal fluid (CSF) is a clear and colorless fluid that occurs between the layers pia mater and arachnoid mater covering central nervous system. CSF is formed by secretory activities of the choroid plexus, the vascular structure lying within the ventricles of brain. CSF primarily acts as a water shock absorber and also acts as a carrier of nutrients and waste products between the blood and the central nervous system. The volume of CSF formed is about 100–250 ml in adults in 24 h. The composition of CSF is same to that of brain extracellular fluid. The ionic composition for CSF is similar to the plasma for some components but differ for many other substances. Generally the composition of sodium, chloride, and magnesium in CSF is same or greater than serum, but potassium, calcium, and glucose are lower than serum. CSF glucose concentration is 60% of serum.

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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Vijay Kumar
    • 1
  • Kiran Dip Gill
    • 2
  1. 1.Department of BiochemistryMaharshi Dayanand UniversityRohtakIndia
  2. 2.Department of BiochemistryPostgraduate Institute of Medical Education & ResearchChandigarhIndia

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