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Arecoline

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Natural Small Molecule Drugs from Plants
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Abstract

Arecoline is extracted from Areca catechu L., and it is the most important alkaloid in it. Arecoline has the effect of antiparasite and is promoting the motility of the gastrointestinal smooth muscle. It activates the M and N cholinergic receptors, excites the nervous system, promotes the body excitability, and improves the ability of learning and memory. The application of arecoline is rare at present mainly due to its adverse effects. However, as an important traditional Chinese medicine, areca still has important value in clinical practice, especially in compatibility of herbs.

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References

  1. Peng W, Liu YJ, Wu N, et al. Areca catechu l. (arecaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology. J Ethnopharmacol. 2015;164:340–56.

    Article  CAS  Google Scholar 

  2. Zheng ZH. Modern research and application of traditional Chinese medicine. Beijing: Academic; 1999.

    Google Scholar 

  3. Wang G, Hu B. Research progress of arecoline. Int J Pathol Clin Med. 2010;30(2):171–5.

    Google Scholar 

  4. Ghelardini C, Galeotti N, Lelli C, et al. M1 receptor activation is a requirement for arecoline analgesia. Farmaco. 2001;56(5–7):383–5.

    Article  CAS  Google Scholar 

  5. Yang YR, Chang KC, Chen CL, et al. Arecoline excites rat locus coeruleus neurons by activating the m2-muscarinic receptor. Chin J Physiol. 2000;43(1):23–8.

    CAS  PubMed  Google Scholar 

  6. Xie DP, Chen LB, Liu CY, et al. Arecoline excites the colonic smooth muscle motility via m3 receptor in rabbits. Chin J Physiol. 2004;47(2):89–94.

    CAS  PubMed  Google Scholar 

  7. Li B, Zhou XZ, Li JY, Yang YJ, Niu JR, Wei XJ, Liu XW, Li JS, Zhang JY. Determination and pharmacokinetic studies of arecoline in dog plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;969:12–8.

    Article  CAS  Google Scholar 

  8. Saikia JR, Schneeweiss FH, Sharan RN. Arecoline-induced changes of poly-adp-ribosylation of cellular proteins and its influence on chromatin organization. Cancer Lett. 1999;139(1):59–65.

    Article  CAS  Google Scholar 

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Correspondence to Guan-Hua Du .

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© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China

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Zhao, Y., Du, LD., Du, GH. (2018). Arecoline. In: Natural Small Molecule Drugs from Plants. Springer, Singapore. https://doi.org/10.1007/978-981-10-8022-7_94

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