Abstract
Securinine is derived from the leaf of securinega suffruticosa Rehd., in which securinine is the most important alkaloid. Securinine mainly has nerve pharmacological activity; it also has antitumor, anti-inflammatory, and antivirus effects, improves bone marrow hematopoietic function, and reduces blood pressure. It has been widely used in clinical practice, mainly for the treatment of polio sequelae and facial nerve palsy. However, there are some adverse reactions in the process of clinical treatment, such as liver damage, elevated serum transaminase, or mild muscle tremor and other nerve stimulation phenomena. Therefore, it is necessary to explore alternatives that have minor side effects and to develop new drugs by applying advanced technology to regulating the clinical application of securinine.
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References
Murav’eva VI, Ban’kovskii AI. Chemical studies on alkaloids from Securinegasemishrub:Securinegasuffruticosa (Pall.)Rehd.Dokl.Akad. NaukSSSR. 1956;110:998–1000.
Yuan W, Lu Z, Liu Y, et al. Three new podocarpane-type diterpenoids from callus of Securinegasuffruticosa. Chem Pharm Bull (Tokyo). 2005;53(12):1610–2.
Liu Y, Yue ZH, Zhang N, et al. Development of research on Securinine. Chin Pharm Aff. 2009;23(8):817–8.
Yuan W. Biosynthesis and biotransformation of Securinega alkaloids. Beijing: Chinese academy of medical sciences, Beijing union medical college; 2005.
Sanakawa U, Ebizuka Y, Yamasaki K. Biosynthesis of securinine, the main alkaloid of Securinegasuffruticosa. Phytochemistry. 1977;16:561–3.
Han G, LaPorte MG, Folmer JJ, et al. Total syntheses of the Securinega alkaloids(+)-14,15-dihydronorsecurinine, (−)-norsecurinine, and phyllanthine. J Org Chem. 2000;65(20):6293–306.
Hu YQ. Chemical reactivity of Securinine and synthesis of dimers and amino acid conjugates of Securinine. Guangdong: Jinan University; 2015.
Lu XJ. Studies on chemical constituents of the leaves of Securinega suffruticosa (Pall.) Rehd. Jilin: Jilin University; 2010.
Weenen H, Nkunya MH, Bray DH, et al. Antimalarial compounds containing an alpha, beta-unsaturated carbonyl moiety from Tanzanian medicinal plants. Planta Med. 1990;56(4):371–3.
Singh AK, Pandey MB, Singh UP. Antifungal activity of an alkaloid allosecurinine against some fungi. Mycobiology. 2007;35(2):62–4.
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© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China
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Wang, DS., Fang, LH., Du, GH. (2018). Securinine. In: Natural Small Molecule Drugs from Plants. Springer, Singapore. https://doi.org/10.1007/978-981-10-8022-7_54
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DOI: https://doi.org/10.1007/978-981-10-8022-7_54
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