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Erycibe Alkaloid II

  • Zhi-Hong Yang
  • Li-Da Du
  • Shou-Bao Wang
  • Guan-Hua DuEmail author
Chapter

Abstract

Erycibe alkaloid II belongs to scopolamine alkaloids, whose chemical structure is different from other known cholinomimetic drugs. Erycibe alkaloid II has the remarkable therapeutic effect on glaucoma by contracting pupil, reducing intraocular pressure, and improving coefficient of aqueous outflow. Its pharmacological potency is similar to that of pilocarpine, while its miotic effect is stronger than that of pilocarpine. Erycibe alkaloid II is suitable for long-term use, because its long-term efficacy was not decreased, without obvious adverse reactions and side effects. So it is an ideal drug for the treatment of glaucoma. Although the content of erycibe alkaloid II is only about one-hundred-thousandth of the original plant, the scientists have done plenty of research on its synthesis and structure-activity relationship. In the foreseeable future, it is expected that erycibe alkaloid II and its new generation of derivatives will have a wide application prospect in the field of glaucoma treatment.

Keywords

Erycibe alkaloid II Cholinergic drug Contracting pupil Glaucoma 

References

  1. 1.
    Fang YW, Zhao JJ, Bian ZL. Structure determination of memantine Dinggongteng EOB. Chemistry. 1981;4:17–8.Google Scholar
  2. 2.
    Yao TR, Chen ZN. Chemical investigation of Chinese medicinal herb, Baogongteng I: the isolation and preliminary study on a new myotic constituent, Bao Gong Teng A. Acta Pharm Sin. 1979;14(12):731–5.Google Scholar
  3. 3.
    Yao TR, Chen ZN, Yi DN, et al. Chemical investigation of Chinese medicinal herb, Baogongteng. Acta Pharm Sin. 1981;16(8):582–8.Google Scholar
  4. 4.
    He HM, Shen JX, Ma XY, et al. The synthesis and pharmacological activities of analogs of erycibe alkaloid II. Acta Pharm Sin. 1989;24(5):335–40.Google Scholar
  5. 5.
    Wang XT, Huang MY, Liang SW. The miotic pharmacological research of Ding gongteng. J New Med. 1978;6:279–80.Google Scholar
  6. 6.
    Huang WY, Peng DY, Zeng SJ, et al. The effect of erycibele erycibe alkaloid on intracellular Ca2+ mobilization of cultured human ciliary muscle cells. Eyescience. 1999;15(4):212–4.Google Scholar
  7. 7.
    Zhou WB, Peng DY, Chen XQ, et al. Studies on Ding gong teng in lowering of intraocular pressure and miosis. Eyescience. 1986;2(3):150–3.Google Scholar
  8. 8.
    Zeng SJ, Zhang YB, Peng DW, et al. Studies of the mechanism of lowering intraocular pressure on Erycibele alkaloid. Chin J Ophthalmol. 1999;35(3):171–3.Google Scholar
  9. 9.
    Cheng BH, Tang HM, Li L, et al. Dynamic observation on the effect of Baogongteng-A on K+, H+ and pO2 and inotropism and chronotropisms of rat heart. J Shanghai Second Med Univ. 1986;2:130–2. 170, 189Google Scholar
  10. 10.
    Huang HH, Yen DH, Wu ML, et al. Acute Erycibe henryi Prain (“Ting Kung Teng”) poisoning. Clin Toxicol (Phila). 2006;44(1):71–5.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  • Zhi-Hong Yang
    • 1
  • Li-Da Du
    • 2
  • Shou-Bao Wang
    • 3
  • Guan-Hua Du
    • 3
    Email author
  1. 1.Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.School of Biomedical SciencesChinese University of Hong KongHong KongChina
  3. 3.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical ScreeningInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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