Erycibe Alkaloid II

  • Zhi-Hong Yang
  • Li-Da Du
  • Shou-Bao Wang
  • Guan-Hua DuEmail author


Erycibe alkaloid II belongs to scopolamine alkaloids, whose chemical structure is different from other known cholinomimetic drugs. Erycibe alkaloid II has the remarkable therapeutic effect on glaucoma by contracting pupil, reducing intraocular pressure, and improving coefficient of aqueous outflow. Its pharmacological potency is similar to that of pilocarpine, while its miotic effect is stronger than that of pilocarpine. Erycibe alkaloid II is suitable for long-term use, because its long-term efficacy was not decreased, without obvious adverse reactions and side effects. So it is an ideal drug for the treatment of glaucoma. Although the content of erycibe alkaloid II is only about one-hundred-thousandth of the original plant, the scientists have done plenty of research on its synthesis and structure-activity relationship. In the foreseeable future, it is expected that erycibe alkaloid II and its new generation of derivatives will have a wide application prospect in the field of glaucoma treatment.


Erycibe alkaloid II Cholinergic drug Contracting pupil Glaucoma 


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© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  • Zhi-Hong Yang
    • 1
  • Li-Da Du
    • 2
  • Shou-Bao Wang
    • 3
  • Guan-Hua Du
    • 3
    Email author
  1. 1.Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.School of Biomedical SciencesChinese University of Hong KongHong KongChina
  3. 3.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical ScreeningInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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