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Cocaine

  • Ying Zhao
  • Jin-Hua Wang
  • Xiu-Ying Yang
  • Guan-Hua DuEmail author
Chapter

Abstract

Cocaine, is also called cocain, was mainly separated from the leaves of coca. Cocaine is white crystal powder and odorless. It is insoluble in water, soluble in chloroform, ethyl ether, ethanol, and other organic solvents. In 1855, cocaine was first extracted from the leaves of herbal ingredients and was used as a local anesthetic in 1840. At present, the clinical dosage form of cocaine is injection, and it is mainly used for local anesthesia in various operations. Cocaine is the first natural alkaloid with local anesthesia effect and is replaced by other anesthetics for its toxic and addictive properties now.

Keywords

Cocaine Coca Anesthesia Addiction 

References

  1. 1.
    Halsted W. Practical comments on the use and abuse of cocaine. NY Med J. 1885;42:294–5.Google Scholar
  2. 2.
    Corning JL. An experimental study. NY Med J. 1885;42:483.Google Scholar
  3. 3.
    Gaedcke F. Ueber das Erythroxylin, dargestellt aus den Blättern des in Südamerika cultivirten Strauches Erythroxylon Coca Lam. Arch Pharm. 1855;132(2):141–50.CrossRefGoogle Scholar
  4. 4.
    Gootenberg P, editor. Cocaine: global histories. London: Routledge; 1999. ISBN 0-203-02646-2Google Scholar
  5. 5.
    Madge T. White mischief: a cultural history of cocaine. Edinburgh: Mainstream Publishing Company; 2001. ISBN 978-1-84018-405-1Google Scholar
  6. 6.
    Spillane JF. Cocaine: from medical marvel to modern menace in the United States, 1884–1920. Baltimore/London: The Johns Hopkins University Press; 2000. ISBN 0-8018-6230-2Google Scholar
  7. 7.
    Bocklisch C, Pascoli V, Wong JC, et al. Cocaine disinhibits dopamine neurons by potentiation of GABA transmission in the ventral tegmental area. Science. 2013;341(6153):1521–5.CrossRefGoogle Scholar
  8. 8.
    Sartor GC, Powell SK, Brothers SP, et al. Epigenetic readers of lysine acetylation regulate cocaine-induced plasticity. J Neurosci Off J Soc Neurosci. 2015;35(45):15062–72.CrossRefGoogle Scholar
  9. 9.
    Maze I, Covington HE, Dietz DM, et al. Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science. 2010;327(5962):213–6.CrossRefGoogle Scholar
  10. 10.
    Nyssen L, Brabant C, Didone V, et al. Response to novelty and cocaine stimulant effects: lack of stability across environments in female Swiss mice. Psychopharmacology. 2015;233:1–10.Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  • Ying Zhao
    • 1
  • Jin-Hua Wang
    • 1
  • Xiu-Ying Yang
    • 1
  • Guan-Hua Du
    • 1
    Email author
  1. 1.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, National Centre for Pharmaceutical ScreeningInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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