Advertisement

Breviscapine

  • Dan-Shu Wang
  • Yu Yan
  • Lian-Hua Fang
  • Guan-Hua DuEmail author
Chapter

Abstract

Breviscapine is extracted from Erigeron breviscapus, the main component of which is scutellarin. Breviscapine has a good pharmacological activity in the treatment of cardiovascular and cerebrovascular diseases. The oral bioavailability of ordinary tablets and granules is very low; at the same time, the half-life of ordinary injection and injection powder is short, eliminating quickly in the body. Therefore, the new preparations for breviscapine such as liposomal injections, microcapsules, sublingual tablets, orally disintegrating tablets, self-emulsifying soft capsules, and other quick-release preparations are in the stage of development.

Keywords

Breviscapine Scutellarin Cardiovascular diseases Cerebrovascular diseases 

References

  1. 1.
    Yunnan Institute of Materia Medica. Study on the chemical components of Erigeron breviscapus. Chin Herb Med Commun. 1976;11:11–4.Google Scholar
  2. 2.
    Yang WY, Zhang Y. The folk application status of Erigeron breviscapus. Chin Med Newsp. 2005;5(31):A07.Google Scholar
  3. 3.
    Cui JM, Wu S. Advances in research on breviscapine. Nat Prod Res Dev. 2003;15(3):255–8.Google Scholar
  4. 4.
    Yang LM, Gu J, Lin MJ, et al. Advances in research on breviscapine. Tianjin Pharm. 2010;22(1):56–60.Google Scholar
  5. 5.
    Zhang XD, Liu J, Zhang WB, et al. Research advance on cardiovascular pharmacological and clinical application of breviscapine. China Pharm. 2007;16(21):3–5.Google Scholar
  6. 6.
    Guo C, Zhu YR, Weng Y, et al. Therapeutic time window and underlying therapeutic mechanism of breviscapine injection against cerebral ischemia/reperfusion injury in rats. J Ethnopharmacol. 2014;151(1):660–6.CrossRefGoogle Scholar
  7. 7.
    Zheng CJ, Ou WL, Shen HY, et al. Combined therapy of diabetic peripheral neuropathy with breviscapine and mecobalamin a systematic review and a meta-analysis of Chinese studies. Biomed Res Int. 2015;2015:680756.PubMedPubMedCentralGoogle Scholar
  8. 8.
    Wei N. Advances of breviscapine in clinical applications and its side-effects. China Pharm. 2011;4(2):144–6.Google Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  • Dan-Shu Wang
    • 1
  • Yu Yan
    • 1
  • Lian-Hua Fang
    • 1
  • Guan-Hua Du
    • 1
    Email author
  1. 1.Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Centre for Pharmaceutical ScreeningInstitute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Personalised recommendations