Tanshinone IIA is extracted from the roots of Salvia miltiorrhiza Bge., which exhibits a variety of pharmacological effects, such as promoting blood circulation and opening the energy channels. In the long history of morphine R&D, the efficacy of tanshinone IIA is mainly concentrated in interfering with the pathological process of cardiovascular diseases. It can reduce intracellular calcium concentration, attenuate the damages from the reactive oxygen species to vascular endothelial cells, and lower the risk of atherosclerosis. For better water solubility, the sodium sulfonate group is introduced for clinical application. The research on tanshinone IIA continues. Current researches show that tanshinone may play a positive role in the treatment of a variety of diseases and has good clinical application prospects.
KeywordsTanshinone IIA Cardiovascular disease Salvia miltiorrhiza Bge.
- 1.Chen WZ. Pharmacological action of Salvia miltiorrhiza. Acta Pharm Sin. 1984;19(11):876–80.Google Scholar
- 2.Du GH, Zhang JT. The general situation and progress of the modern research of red sage root. Her Med. 2004;23(6):355–60.Google Scholar
- 3.Chen WZ, Dong YL, Wang CG, Ding GS. Pharmacological study of tanshinone IIA sodium sulfonate. Acta Pharm Sin. 1979;05:277–83.Google Scholar
- 4.Gao YG, Song YM, Yang YY, Tang JX, Liu WF. Pharmacological study of tanshinone. Acta Pharm Sin. 1979;14(02):75–82.Google Scholar
- 7.Zhang MT, Qian YH, Tang AQ. Advances in pharmacological effects of tanshinone IIA. Med Recapitulate. 2010;16(17):2661–4.Google Scholar
- 8.Bai FM. Clinical application of tanshinone IIA sodium sulfonate. China Pharm. 2012;23(31):2971–3.Google Scholar