Reserpine is extracted from indole alkaloid, which is one of the most important alkaloids in Rauvolfia. Reserpine has a medium antihypertensive effect, and its initial effect is slow but lasts long. However, due to the insufficient clinical data and the adverse effect of reserpine, such as depression, Parkinson’s disease, dizziness, nightmare, nasal congestion, headache, diarrhea, abdominal pain, inattention, and suicidal tendencies, reserpine has already been eliminated in foreign countries, and in China, it is only used as a second-line antihypertensive drug. In the history of reserpine R&D, large scales of studies about Chinese Rauvolfia as well as the numerous participants promote the rapid progress of natural medicine. It can be taken as the earliest study in plant medicine since the founding of China, providing valuable experience to our later studies.
KeywordsReserpine Rauvolfia Antihypertension
- 3.Liu-Lisheng. Guidelines for prevention and treatment of hypertension in China, 2010. Guidelines on the rational use of drugs in hypertension. Chin J Front Med Sci (Electronic Version). 2015;7(6):22–3.Google Scholar
- 4.Institute of Materia Medica. Chinese academy of medical science and Peking Union Medical College. Modern research of Chinese herbal medicine. Beijing: Beijing Medical University and Peking Union Medical College Associated Press; 1995. p. 306–25.Google Scholar
- 7.Liu-xiu. Application of reserpine in perioperative period of hypertension. Shandong Med J. 2015;9:103–4.Google Scholar
- 8.Yang-Yue. Taking antihypertensive drugs as an example for systematic review of WHO for essential drugs. China Pharm. 2011;22(32):2990–3.Google Scholar