Abstract
Reserpine is extracted from indole alkaloid, which is one of the most important alkaloids in Rauvolfia. Reserpine has a medium antihypertensive effect, and its initial effect is slow but lasts long. However, due to the insufficient clinical data and the adverse effect of reserpine, such as depression, Parkinson’s disease, dizziness, nightmare, nasal congestion, headache, diarrhea, abdominal pain, inattention, and suicidal tendencies, reserpine has already been eliminated in foreign countries, and in China, it is only used as a second-line antihypertensive drug. In the history of reserpine R&D, large scales of studies about Chinese Rauvolfia as well as the numerous participants promote the rapid progress of natural medicine. It can be taken as the earliest study in plant medicine since the founding of China, providing valuable experience to our later studies.
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References
Monachino J. Rauvolfia serpentina – its history, botany and medical use. Econ Bot. 1954;8:349–65.
Woodward RB, Bader FE, Bickel H, et al. The total synthesis of reserpine. Tetrahedron. 1958;2(1):1–57.
Liu-Lisheng. Guidelines for prevention and treatment of hypertension in China, 2010. Guidelines on the rational use of drugs in hypertension. Chin J Front Med Sci (Electronic Version). 2015;7(6):22–3.
Institute of Materia Medica. Chinese academy of medical science and Peking Union Medical College. Modern research of Chinese herbal medicine. Beijing: Beijing Medical University and Peking Union Medical College Associated Press; 1995. p. 306–25.
Blasco-Serra A. Depressive-like symptoms in a reserpine-induced model of fibromyalgia in rats. Physiol Behav. 2015;151:456–62.
Catiuscia Molz de Freitas. Behavioral and neurochemical effects induced by reserpine in mice. Psychopharmacology. 2016;233(3):457–67.
Liu-xiu. Application of reserpine in perioperative period of hypertension. Shandong Med J. 2015;9:103–4.
Yang-Yue. Taking antihypertensive drugs as an example for systematic review of WHO for essential drugs. China Pharm. 2011;22(32):2990–3.
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© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China
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Chen, Y., Sun, L., Du, GH. (2018). Reserpine. In: Natural Small Molecule Drugs from Plants. Springer, Singapore. https://doi.org/10.1007/978-981-10-8022-7_21
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DOI: https://doi.org/10.1007/978-981-10-8022-7_21
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