• Guo-Rong He
  • Shou-bao Wang
  • Guan-Hua DuEmail author


Ligustrazine is extracted from chuanxiong 川芎 (Ligusticum chuanxiong Hort; L. wallichii), which is the most important alkaloid in chuanxiong. Studies have demonstrated that ligustrazine is effective at promoting blood flow, the circulation of Qi, and the removal of blood stasis, so it has been extensively used to treat ischemic cardiovascular and cerebrovascular diseases, such as atherosclerosis, hypertension, and stroke. Ligustrazine has also used to treat children with viral myocarditis, chronic renal failure, hepatic fibrosis, portal hypertension, tumors, and diabetic nephropathy. Ligustrazine can relieve symptoms rapidly, and its effect is stable and lasting. It has good spread of the value in clinic. To decide the specificity of ligustrazine used in clinic, we carried out a large-sample, multicenter, randomized, double-blind, placebo-controlled trial, which provides evidences for the extensive use of ligustrazine in clinic.


Ligustrazine Alkaloid Antiapoptosis Promoting blood circulation 


  1. 1.
    Jia L, Sun X. Research progress of Chinese herbal medicine Ligusticum Wallichii. Heilongjiang Sci Technol Inform. 2009;11:146–7.Google Scholar
  2. 2.
    Kosuge T, Kamiya H. Discovery of a pyrazine in a natural product: tetramethylpyrazine from cultures of a strain of Bacillus subtilis. Nature. 1962;193:776.CrossRefGoogle Scholar
  3. 3.
    Chen K, Qian Z, Zhang W, et al. Efficacy of Ligustrazine in the treatment of acute occlusive cerebrovascular disease. Report on coordination meeting of ligustrazine in Beijing 1975.Google Scholar
  4. 4.
    Jiang F, Qian J, Chen S, et al. Ligustrazine improves atherosclerosis in rat via attenuation of oxidative stress. Pharm Biol. 2011;49(8):856–63.CrossRefGoogle Scholar
  5. 5.
    Tan F, Fu W, Cheng N, et al. Ligustrazine reduces blood-brain barrier permeability in a rat model of focal cerebral ischemia and reperfusion. Exp Ther Med. 2015;9(5):1757–62.CrossRefGoogle Scholar
  6. 6.
    Jiang Y, Chen K. Pharmacological effects and clinical application of ligustrazine on cardiovascular and cerebrovascular diseases. Chin J Integr Tradit West Med. 2013;33(5):707–11.Google Scholar
  7. 7.
    Wu W. The clinical curative effect of Ligustrazine and citicoline sodium combined with diphenhydramine hydrochloride in treatment of vertigo syndrome. China Mod Med. 2011;18(4):51–5.Google Scholar
  8. 8.
    Li X, Chen Y. Efficacy of ligustrazine in the treatment of tension headache. Chin J Pract Nerv Dis. 2010;13(18):64–5.Google Scholar
  9. 9.
    Dong M, Li Y, Ge N, et al. Curative efficacy of Qingxuan decoction combined with ligustrazine injection in the treatment of vertebrobasilar insufficiency. Beijing J Tradit Chin Med. 2011;30(1):8–10.Google Scholar
  10. 10.
    Peng X. Efficacy of ligustrazine injection in treatment of viral myocarditis in children. J Youjiang Med Univ Natl. 2010;3:376–7.Google Scholar

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© Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China 2018

Authors and Affiliations

  1. 1.Beijing Key Laboratory of Drug Targets Identification and Drug ScreeningCentre for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

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