Abstract
Quinine commonly known as cinchona alkaloid belongs to the alkaloids from natural compounds, extracted from the bark of Rubiaceae plant and cinchona tree. Quinine is the antidote to malaria; the discovery and application of it have saved millions of malaria patients. Biological activity study proved that quinine could kill all kinds of parasite schizonts; it mainly affects the life cycle of the parasite by effectively controlling the developmental conditions. It is mainly used for clinical treatment of not only falciparum malaria caused by chloroquine-resistant strains of plasmodium falciparum but also plasmodium vivax malaria.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
der Kenntnis RPZ. Chinaalkaloide. VII. Mitteilung: Über ein neues oxydationsprodukt des Cinchonins. Ber Dtsch Chem Ges. 1907;40(3):3655–8.
Rabe P, Kindler K. Cinchona alkaloids. XIX. Partial synthesis of quinine. Ber Dtsch Chem Ges. 1918;51:466–7.
Prostenik M, Prelog V. Synthetic experiments in the series of the cinchona alkaloids. IV. Homomeroquinene and the partial synthesis of quinotoxine. Helv Chim Acta. 1943;26:1965–71.
Rui-Xia G. Historical story on natural medicinal chemistry: isolation, structure, and total synthesis of quinine. Chin Tradit Herb Drug. 2014;45(19):2737–41.
Achan J, Talisuna AO, Erhart A, et al. Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria. Malar J. 2011;10(144):1–12.
Ruocco V, Ruocco E, Schwartz RA, et al. Kaposi sarcoma and quinine: a potentially overlooked triggering factor in millions of Africans. J Am Acad Dermatol. 2011;64(2):434–6.
Dias DA, Urban S, Roessner U. A historical overview of natural products in drug discovery. Metabolites. 2012;2(2):303–36.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China
About this chapter
Cite this chapter
Wen, L., Yuan, YH., Kong, LL., Chen, NH. (2018). Quinine. In: Natural Small Molecule Drugs from Plants. Springer, Singapore. https://doi.org/10.1007/978-981-10-8022-7_100
Download citation
DOI: https://doi.org/10.1007/978-981-10-8022-7_100
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-8021-0
Online ISBN: 978-981-10-8022-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)