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Can We Rebuild the Cell Membrane?

  • Samar Damiati
Chapter

Abstract

Biomimetic artificial membranes are convenient, versatile models that borrow from the principles of biological systems and mimic the physiological characteristics of natural cell membranes by exploiting simple nanostructured materials. To construct an artificial membrane, it is important to first understand the biology of natural membranes and to recognize the primary differences between the cellular membranes of different organisms. The creation of biomimetic membranes can be achieved with a minimal number of living or non-living components while sufficiently retaining the basic properties of cellular life. The successful development of biomimetic membranes promotes an understanding of basic cellular functions and assists in the generation of semi-natural systems with new functions, the fabrication of selective and sensitive biosensing platforms, and the development of new biotechnology in different fields ranging from medicine to the environment. This chapter presents the most common model biomimetic membranes that are currently available and their applications, as well as their preparation methods, general investigation techniques, properties, and limitations.

Keywords

Biological membranes Biomimetic model membranes Supported lipid membranes Lipid vesicles Membrane proteins Biosensing platforms Nanostructured materials 

Abbreviations

3D

Three-dimensional

AFM

Atomic Force Microscopy

BLM

Black Lipid Membrane

CL

Cardiolipin

EIS

Electrochemical Impedance Spectroscopy

GUVs

Giant Unilamellar Vesicles

hBLM

Hybrid Bilayer Lipid Membrane

HDL

High-Density Lipoprotein

LB

Langmuir-Blodgett

LS

Langmuir-Schaefer

LTA

Lipoteichoic Acids

LUVs

Large Unilamellar Vesicles

MLVs

Multilamellar Lipid Vesicles

MSP

Membrane Scaffolding Protein

PC

Phosphatidylcholine

PE

Phosphatidylethanolamine

PG

Phosphatidylglycerol

PI

Phosphatidylinositol

PS

Phosphatidylserine

QCM-D

Quartz Crystal Microbalance with Dissipation monitoring

S-layer

Surface-layer

SAM

Self-Assembling Monolayer

sLBM

Supported Lipid Bilayer Membrane

SM

Sphingomyelin

SsLBM

S-layer-supported Lipid Bilayer Membrane

SUVs

Small Unilamellar Vesicles

tBLM

Tethered Bilayer Lipid Membrane

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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of Biochemistry, Faculty of ScienceKing Abdulaziz University (KAU)JeddahSaudi Arabia
  2. 2.Institute for Synthetic Bioarchitectures, Department of NanobiotechnologyUniversity of Natural Resources and Life Sciences (BOKU)ViennaAustria

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