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Recent Advances in Electrospun Poly(ε-caprolactone)-Based Materials and Their Biomedical Applications

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Abstract

Fiber-based materials have been used in a wide range of applications, from textiles to biofunctional scaffolds, and research on these materials continues to yield new and exciting results. In the past decades, electrospinning has been shown to be a particularly versatile and adaptable method of fiber formation. A great number of variables in the electrospinning process can be finely tuned to alter the resultant properties of the electrospun materials. Among all published research on electrospinning, poly(ε-caprolactone) (PCL)-based electrospun fibers have been most intensively studied due to the low cost, good processability, great biocompatibility, and biodegradability of PCL. This chapter highlights the current advances in electrospun PCL-based materials by categorizing these materials into following six groups: (1) PCL-natural biopolymer-based material, (2) PCL blended with other biodegradable synthetic polymers, (3) PCL blended with other synthetic polymers, (4) PCL fibers functionalization utilizing bioactive molecules, (5) PCL-based composites with inorganics or other nanofillers, and (6) PCL fiber with post-electrospinning decoration. We also summarize the fabrication techniques, experimental parameters, as well as the structure, morphology, and physicochemical properties of these fiber products. This chapter provides a comprehensive review of fabricating various PCL-based electrospun materials and their potential applications as biodegradable and biocompatible materials, such as biomedical implants, tissue scaffolds, drug carriers, gene delivery vehicles.

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Abbreviations

AA:

Acetic acid

DCM:

Dichloromethane

DMAc:

N, N-dimethylacetamide

DMF:

N, N-imethylformamide

DMK:

Acetone

EtOH:

Ethanol

FA:

Formic acid

HFP:

1,1,1,3,3,3-hexafluor-2-propanol

MC:

Methyl chloride

MEK:

Methyl ethyl ketone

MeOH:

Methanol

TCM:

Chloroform

TEF:

2,2,2-trifluoroethanol

TFA:

Trifluoroacetic acid

THF:

Tetrahydrofuran

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Acknowledgements

Authors would like to thank Central Michigan University for Provost Discretionary Grant (cc26151). Lin Wang would like to thank Beijing University of Technology for the Joint Training Scholarship Program (2016).

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, MI, 48859, USA

    Lin Wang, Reem A. Ghubayra, Adam J.-P. Bauer, Mir Hadi R. Kondelaji, Zachary B. Grim & Bingbing Li

  2. Beijing Key Laboratory for Green Catalysis and Separation, College of Environmental and Energy Engineering, Beijing University of Technology, Beijing, 100124, People’s Republic of China

    Lin Wang

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  1. Lin Wang
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  2. Reem A. Ghubayra
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  3. Adam J.-P. Bauer
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  4. Mir Hadi R. Kondelaji
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  6. Bingbing Li
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Correspondence to Bingbing Li .

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  1. Department of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, Michigan, USA

    Bingbing Li

  2. School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, China

    Tifeng Jiao

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Wang, L., Ghubayra, R.A., Bauer, A.JP., Kondelaji, M.H.R., Grim, Z.B., Li, B. (2018). Recent Advances in Electrospun Poly(ε-caprolactone)-Based Materials and Their Biomedical Applications. In: Li, B., Jiao, T. (eds) Nano/Micro-Structured Materials for Energy and Biomedical Applications. Springer, Singapore. https://doi.org/10.1007/978-981-10-7787-6_3

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