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Early-stage Lung Cancer pp 103–123Cite as

Tumor Dormancy and Angiogenesis-Dependent Progression

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Abstract

Tumor development and progression correlate with the ability of the tumor to induce vascular development in the microenvironment. The nutritional supply is limited at the avascular stage, and the tumor remains in a state of dormancy or growth inertia; tumor cell apoptosis and proliferation maintain a dynamic balance. Angiogenic switch activation and subsequent angiogenesis are critical biological events that signal the initiation of tumor progression as dormancy ends. Besides the perfusion of nutrition to the tumor, neovessels have the paracrine function via endothelial cells and secrete various growth factors to stimulate vascular proliferation and accelerate tumor differentiation and invasion. Angiogenesis improves blood supply to the tumor and reflects a change in biological behavior: specifically, a transition from a dormant status to an active one or from low-grade malignancy to intermediate- or high-grade malignancy. Hence, the early detection and scrutiny of novel vessels related to tumors are vital for the assessment of disease progression and making decisions about proper medical intervention. In this chapter, tumor dormancy, angiogenic switch, angiogenesis, and the characterization of neovasculature will be discussed.

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Authors and Affiliations

  1. Department of Radiation Oncology, Fudan University Huadong Hospital, Shanghai, China

    Xiangpeng Zheng

  2. Department of Radiology, Fudan University Huadong Hospital, Shanghai, China

    Ming Li & Guozhen Zhang

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  1. Xiangpeng Zheng
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  2. Ming Li
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  3. Guozhen Zhang
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Correspondence to Xiangpeng Zheng .

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Editors and Affiliations

  1. Fudan University Huadong Hospital , Shanghai, China

    Xiangpeng Zheng

  2. Fudan University Huadong Hospital , Shanghai, China

    Ming Li

  3. Fudan University Huadong Hospital , Shanghai, China

    Guozhen Zhang

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© 2018 Springer Nature Singapore Pte Ltd. and People's Military Medical Press

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Zheng, X., Li, M., Zhang, G. (2018). Tumor Dormancy and Angiogenesis-Dependent Progression. In: Zheng, X., Li, M., Zhang, G. (eds) Early-stage Lung Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-10-7596-4_5

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  • DOI: https://doi.org/10.1007/978-981-10-7596-4_5

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  • Online ISBN: 978-981-10-7596-4

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