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Molecular Aspects of Plant-Pathogen Interaction pp 115–138Cite as

Role of NBS-LRR Proteins in Plant Defense

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Abstract

The NBS-LRR proteins are encoded by one of the largest and most important gene family involved in disease resistance in plants. Many of these NBS-LRR proteins recognize effectors secreted by pathogens directly or indirectly that in turn activate downstream signaling pathways leading to activation of plant defense response against various classes of pathogens including bacterial, fungal, viral, nematode and insect. Defense response by NBS-LRR protein is a sophisticated strategy that induces effector-triggered immunity (ETI). The NBS-LRR proteins comprised of amino-terminal variable domain, a central nucleotide-binding site (NBS) and carboxy-terminal leucine-rich repeats (LRR) domain. The NBS domain binds and hydrolyzes ATP and primarily functions as a signal transduction switch following pathogen recognition. LRRs are highly adaptable structural domains that are involved in protein-protein interactions, and these LRRs can also evolve very different binding specificities. In the following chapter we have discussed in detail about the present knowledge pertaining to NBS-LRR class of proteins and their prospect in crop improvement against diseases.

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Acknowledgment

We are thankful to the Director of CSIR-IHBT, Palampur, for his kind support. We acknowledge the financial support from SERB-DST, New Delhi, under the Fast Track Scheme for Young Scientists (YSS/2015/001036). Namo Dubey acknowledges UGC for providing fellowship. The CSIR-IHBT communication number for this article is 4141.

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  1. Molecular Plant Pathology Laboratory, Division of Biotechnology, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, India

    Namo Dubey & Kunal Singh

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  1. Namo Dubey
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  2. Kunal Singh
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Correspondence to Kunal Singh .

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Editors and Affiliations

  1. Department of Botany, Hans Raj College, University of Delhi, New Delhi, India

    Archana Singh

  2. Molecular Biology Research Laboratory, Department of Zoology, Deshbandhu College, University of Delhi, New Delhi, India

    Indrakant K. Singh

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Dubey, N., Singh, K. (2018). Role of NBS-LRR Proteins in Plant Defense. In: Singh, A., Singh, I. (eds) Molecular Aspects of Plant-Pathogen Interaction. Springer, Singapore. https://doi.org/10.1007/978-981-10-7371-7_5

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