Role of NBS-LRR Proteins in Plant Defense

  • Namo Dubey
  • Kunal Singh


The NBS-LRR proteins are encoded by one of the largest and most important gene family involved in disease resistance in plants. Many of these NBS-LRR proteins recognize effectors secreted by pathogens directly or indirectly that in turn activate downstream signaling pathways leading to activation of plant defense response against various classes of pathogens including bacterial, fungal, viral, nematode and insect. Defense response by NBS-LRR protein is a sophisticated strategy that induces effector-triggered immunity (ETI). The NBS-LRR proteins comprised of amino-terminal variable domain, a central nucleotide-binding site (NBS) and carboxy-terminal leucine-rich repeats (LRR) domain. The NBS domain binds and hydrolyzes ATP and primarily functions as a signal transduction switch following pathogen recognition. LRRs are highly adaptable structural domains that are involved in protein-protein interactions, and these LRRs can also evolve very different binding specificities. In the following chapter we have discussed in detail about the present knowledge pertaining to NBS-LRR class of proteins and their prospect in crop improvement against diseases.


Plant Defense NBS-LRR R-Genes Effectors Phytopathogens 



We are thankful to the Director of CSIR-IHBT, Palampur, for his kind support. We acknowledge the financial support from SERB-DST, New Delhi, under the Fast Track Scheme for Young Scientists (YSS/2015/001036). Namo Dubey acknowledges UGC for providing fellowship. The CSIR-IHBT communication number for this article is 4141.


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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Molecular Plant Pathology Laboratory, Division of BiotechnologyCSIR-Institute of Himalayan Bioresource TechnologyPalampurIndia

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