Abstract
Protein-protein interaction (PPI) is an important biological phenomenon. Therefore, it is of interest to study PPI. The importance is PPI in hetero multimer protein complexes is of significance. There are 384 high-resolution (<3 Å) non-redundant (at 30% sequence similarity cutoff) known hetero multimer (of forms ABC, A2B, ABCD, A2B2, A2B2C2, A3B3) structural protein complexes at the protein data bank increasing gradually providing valuable insights to complex biological events. We provide an account of known hetero multimer protein complex structures in this chapter. A comprehensive analysis of these complexes will provide valuable insights to the understanding intricate issues in multi subunit protein complex assemblies.
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References
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Exercises
Exercises
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1.
What are hetero multimer protein complexes?
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2.
Illustrate a flowchart to create a dataset of hetero multimer protein complexes.
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3.
Show the distribution of hetero multimer protein complexes based on the number of subunits.
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4.
Illustrate a hetero ABC trimer protein complex using an example.
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5.
How many subunits constitute a pentamer and illustrate using an example?
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6.
Give an account of sequence dissimilarity among subunits in an ABC hetero trimer.
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7.
A2B2 hetero tetramer protein complexes are highly represented in PDB. Discuss in detail.
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8.
Illustrate the difference between ABCD and A2B2 tetramer using examples.
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9.
Illustrate the difference between ABC and A2B trimer using examples.
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10.
Discuss A2B2C2 hexamer protein complex using an example.
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Kangueane, P., Nilofer, C. (2018). Hetero Multimer Protein Complexes. In: Protein-Protein and Domain-Domain Interactions. Springer, Singapore. https://doi.org/10.1007/978-981-10-7347-2_6
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DOI: https://doi.org/10.1007/978-981-10-7347-2_6
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Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-7346-5
Online ISBN: 978-981-10-7347-2
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