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An Ions-Medicated Single Molecular Multi-functional DNA Cascade Logic Circuit and Signal Amplifier Model

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Bio-inspired Computing: Theories and Applications (BIC-TA 2017)

Part of the book series: Communications in Computer and Information Science ((CCIS,volume 791))

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In this paper, a single molecular multi-functional DNA cascade logic circuit and signal amplifier model was demonstrated by two single molecular multi-functional ions DNA probe(SMIP) to detect environment mercury and silver ion pollution, these two SMIP random coil structures turned into different hairpin-like structures with T-Hg\(^{2+}\)-T or C-Ag\(^{+}\)-C via inputting mercury and silver ions, then, use the SMIP structure “OR” and “AND” logic gate and unimolecular mulfunctional DNA logic amplifier model (UMDA). Finally, we proved the feasibility of our model by PAGE and fluorescence alteration.

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This work is supported by the National Natural Science Foundation of China under Grant No. 61572302 and No. 61272246.

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Correspondence to Yafei Dong .

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Guo, B., Chen, X., Wu, T., Dong, Y. (2017). An Ions-Medicated Single Molecular Multi-functional DNA Cascade Logic Circuit and Signal Amplifier Model. In: He, C., Mo, H., Pan, L., Zhao, Y. (eds) Bio-inspired Computing: Theories and Applications. BIC-TA 2017. Communications in Computer and Information Science, vol 791. Springer, Singapore.

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-7178-2

  • Online ISBN: 978-981-10-7179-9

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