An Ions-Medicated Single Molecular Multi-functional DNA Cascade Logic Circuit and Signal Amplifier Model

  • Bingjie Guo
  • Xiangxiang Chen
  • Tao Wu
  • Yafei DongEmail author
Conference paper
Part of the Communications in Computer and Information Science book series (CCIS, volume 791)


In this paper, a single molecular multi-functional DNA cascade logic circuit and signal amplifier model was demonstrated by two single molecular multi-functional ions DNA probe(SMIP) to detect environment mercury and silver ion pollution, these two SMIP random coil structures turned into different hairpin-like structures with T-Hg\(^{2+}\)-T or C-Ag\(^{+}\)-C via inputting mercury and silver ions, then, use the SMIP structure “OR” and “AND” logic gate and unimolecular mulfunctional DNA logic amplifier model (UMDA). Finally, we proved the feasibility of our model by PAGE and fluorescence alteration.


Molecular Multi-functional Ions-medicated DNA computing 



This work is supported by the National Natural Science Foundation of China under Grant No. 61572302 and No. 61272246.


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Copyright information

© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  • Bingjie Guo
    • 1
  • Xiangxiang Chen
    • 3
  • Tao Wu
    • 2
  • Yafei Dong
    • 1
    • 2
    Email author
  1. 1.College of life sciencesShannxi Normal universityXi’anChina
  2. 2.College of computer sciencesShannxi Normal universityXi’anChina
  3. 3.Software Institute, ShaanXi Electronic Technical CollegeXi’anChina

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