Skip to main content
SpringerLink
Log in

Pregnancy Complications in Women with Adenomyosis

  • Chapter
  • First Online:
Uterine Fibroids and Adenomyosis

Part of the book series: Comprehensive Gynecology and Obstetrics ((CGO))

  • 748 Accesses

Abstract

The risk of pregnancy complications in women with adenomyosis is debatable. However, only a limited number of studies on pregnancies in women with adenomyosis have been reported. Some control studies and a retrospective survey demonstrated that the risk of pregnancy complications, including miscarriage, preterm delivery, pregnancy-induced hypertension (PIH), fetal growth restriction (FGR), cervical incompetency, and uterine infection, was increased in pregnant women with adenomyosis. Although some studies have evaluated whether medication or surgical management can influence the pregnancy outcomes in women with adenomyosis, there is currently no evidence to suggest that medication or surgical intervention has any benefit in terms of the pregnancy complications in women with adenomyosis. The size and type of adenomyosis are important factors for pregnancy complications. We should be aware of the potential for pregnancy complications, especially in pregnant women with diffuse-type adenomyosis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bergholt T, Eriksen L, Berendt N, Jacobsen M, Hertz JB. Prevalence and risk factors of adenomyosis at hysterectomy. Hum Reprod. 2001;16:2418–21.

    Article  CAS  PubMed  Google Scholar 

  2. McCausland V, McCausland A. The response of adenomyosis to endometrial ablation/resection. Hum Reprod Update. 1998;4:350–9.

    Article  CAS  PubMed  Google Scholar 

  3. Parazzini F, Vercellini P, Panazza S, Chatenoud L, Oldani S, Crosignani PG. Risk factors for adenomyosis. Hum Reprod. 1997;12:1275–9.

    Article  CAS  PubMed  Google Scholar 

  4. Vercellini P, Parazzini F, Oldani S, Panazza S, Bramante T, Crosignani PG. Adenomyosis at hysterectomy: a study on frequency distribution and patient characteristics. Hum Reprod. 1995;10:1160–2.

    Article  CAS  PubMed  Google Scholar 

  5. Azziz R. Adenomyosis in pregnancy. A review. J Reprod Med. 1986;31:224–7.

    PubMed  CAS  Google Scholar 

  6. Maheshwari A, Gurunath S, Fatima F, Bhattacharya S. Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes. Hum Reprod Update. 2012;18:374–92.

    Article  PubMed  Google Scholar 

  7. Vercellini P, Consonni D, Dridi D, Bracco B, Frattaruolo MP, Somigliana E. Uterine adenomyosis and in vitro fertilization outcome: a systematic review and meta-analysis. Hum Reprod. 2014;29:964–77.

    Article  PubMed  Google Scholar 

  8. Brosens I, Derwig I, Brosens J, Fusi L, Benagiano G, Pijnenborg R. The enigmatic uterine junctional zone: the missing link between reproductive disorders and major obstetrical disorders? Hum Reprod. 2010;25:569–74.

    Article  PubMed  Google Scholar 

  9. Brosens I, Pijnenborg R, Benagiano G. Defective myometrial spiral artery remodelling as a cause of major obstetrical syndromes in endometriosis and adenomyosis. Placenta. 2013;34:100–5.

    Article  CAS  PubMed  Google Scholar 

  10. Brosens I, Pijnenborg R, Vercruysse L, Romero R. The “Great Obstetrical Syndromes” are associated with disorders of deep placentation. Am J Obstet Gynecol. 2011;204:193–201.

    Article  PubMed  Google Scholar 

  11. Bergeron C, Amant F, Ferenczy A. Pathology and physiopathology of adenomyosis. Best Pract Res Clin Obstet Gynaecol. 2006;20:511–21.

    Article  PubMed  Google Scholar 

  12. Costello MF, Lindsay K, McNally G. The effect of adenomyosis on in vitro fertilisation and intra-cytoplasmic sperm injection treatment outcome. Eur J Obstet Gynecol Reprod Biol. 2011;158:229–34.

    Article  PubMed  Google Scholar 

  13. Hashimoto A, Iriyama T, Sayama S, Nakayama T, Komatsu A, Miyauchi A, Nishii O, Nagamatsu T, Osuga Y, Fujii T. Adenomyosis and adverse perinatal outcomes: increased risk of second trimester miscarriage, preeclampsia, and placental malposition. J Matern Fetal Neonatal Med. 2018;31:1–6.

    Article  Google Scholar 

  14. Martinez-Conejero JA, Morgan M, Montesinos M, Fortuno S, Meseguer M, Simon C, Horcajadas JA, Pellicer A. Adenomyosis does not affect implantation, but is associated with miscarriage in patients undergoing oocyte donation. Fertil Steril. 2011;96:943–50.

    Article  PubMed  Google Scholar 

  15. Mijatovic V, Florijn E, Halim N, Schats R, Hompes P. Adenomyosis has no adverse effects on IVF/ICSI outcomes in women with endometriosis treated with long-term pituitary down-regulation before IVF/ICSI. Eur J Obstet Gynecol Reprod Biol. 2010;151:62–5.

    Article  CAS  PubMed  Google Scholar 

  16. Salim R, Riris S, Saab W, Abramov B, Khadum I, Serhal P. Adenomyosis reduces pregnancy rates in infertile women undergoing IVF. Reprod Biomed Online. 2012;25:273–7.

    Article  PubMed  Google Scholar 

  17. Tamura H, Kishi H, Kitade M, Asai-Sato M, Tanaka A, Murakami T, Minegishi T, Sugino N. Clinical outcomes of infertility treatment for women with adenomyosis in Japan. Reprod Med Biol. 2017;16(3):276–82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Tamura H, Kishi H, Kitade M, Asai-Sato M, Tanaka A, Murakami T, Minegishi T, Sugino N. Impact of adenomyosis on complications and outcomes of pregnancy in Japan. Reprod Med Biol. 2017;16(4):330–6.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Youm HS, Choi YS, Han HD. In vitro fertilization and embryo transfer outcomes in relation to myometrial thickness. J Assist Reprod Genet. 2011;28:1135–40.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Shiozaki A, Matsuda Y, Hayashi K, Satoh S, Saito S. Comparison of risk factors for major obstetric complications between Western countries and Japan: a case-cohort study. J Obstet Gynaecol Res. 2011;37:1447–54.

    Article  PubMed  Google Scholar 

  21. Juang CM, Chou P, Yen MS, Twu NF, Horng HC, Hsu WL. Adenomyosis and risk of preterm delivery. BJOG. 2007;114:165–9.

    Article  PubMed  Google Scholar 

  22. Ota H, Igarashi S, Sasaki M, Tanaka T. Distribution of cyclooxygenase-2 in eutopic and ectopic endometrium in endometriosis and adenomyosis. Hum Reprod. 2001;16:561–6.

    Article  CAS  PubMed  Google Scholar 

  23. Carrarelli P, Yen CF, Funghi L, Arcuri F, Tosti C, Bifulco G, Luddi A, Lee CL, Petraglia F. Expression of inflammatory and neurogenic mediators in adenomyosis. Reprod Sci. 2017;24:369–75.

    Article  CAS  PubMed  Google Scholar 

  24. Sotnikova N, Antsiferova I, Malyshkina A. Cytokine network of eutopic and ectopic endometrium in women with adenomyosis. Am J Reprod Immunol. 2002;47:251–5.

    Article  PubMed  Google Scholar 

  25. Acar S, Millar E, Mitkova M, Mitkov V. Value of ultrasound shear wave elastography in the diagnosis of adenomyosis. Ultrasound. 2016;24:205–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Ferenczy A. Pathophysiology of adenomyosis. Hum Reprod Update. 1998;4:312–22.

    Article  CAS  PubMed  Google Scholar 

  27. Guo SW, Mao X, Ma Q, Liu X. Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression of oxytocin receptor (OTR) in women with symptomatic adenomyosis. Fertil Steril. 2013;99:231–40.

    Article  CAS  PubMed  Google Scholar 

  28. Mochimaru A, Aoki S, Oba MS, Kurasawa K, Takahashi T, Hirahara F. Adverse pregnancy outcomes associated with adenomyosis with uterine enlargement. J Obstet Gynaecol Res. 2015;41(4):529–33.

    Article  PubMed  Google Scholar 

  29. Mercer BM. Preterm premature rupture of the membranes. Obstet Gynecol. 2003;101:178–93.

    PubMed  Google Scholar 

  30. Parry S, Strauss JF III. Premature rupture of the fetal membranes. N Engl J Med. 1998;338:663–70.

    Article  CAS  PubMed  Google Scholar 

  31. Soydinc HE, Sak ME, Evliyaoglu O, Evsen MS, Turgut A, Ozler A, Yildiz I, Gul T. Prolidase, matrix metalloproteinases 1 and 13 activity, oxidative-antioxidative status as a marker of preterm premature rupture of membranes and chorioamnionitis in maternal vaginal washing fluids. Int J Med Sci. 2013;10:1344–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Milne F, Redman C, Walker J, Baker P, Bradley J, Cooper C, de Swiet M, Fletcher G, Jokinen M, Murphy D, et al. The pre-eclampsia community guideline (PRECOG): how to screen for and detect onset of pre-eclampsia in the community. BMJ. 2005;330:576–80.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R. Pre-eclampsia. Lancet. 2010;376:631–44.

    Article  PubMed  Google Scholar 

  34. Leyendecker G. Redefining endometriosis: endometriosis is an entity with extreme pleiomorphism. Hum Reprod. 2000;15:4–7.

    Article  CAS  PubMed  Google Scholar 

  35. Yorifuji T, Makino S, Yamamoto Y, Sugimura M, Kuwatsuru R, Takeda S. Time spatial labeling inversion pulse magnetic resonance angiography in pregnancy with adenomyosis. J Obstet Gynaecol Res. 2013;39:1480–3.

    PubMed  Google Scholar 

  36. Erguvan R, Meydanli MM, Alkan A, Edali MN, Gokce H, Kafkasli A. Abscess in adenomyosis mimicking a malignancy in a 54-year-old woman. Infect Dis Obstet Gynecol. 2003;11:59–64.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Weng SF, Yang SF, Wu CH, Chan TF. Microabscess within adenomyosis combined with sepsis. Kaohsiung J Med Sci. 2013;29:400–1.

    Article  PubMed  Google Scholar 

  38. Kim SC, Lee NK, Yun KY, Joo JK, Suh DS, Kim KH. A rapidly growing adenomyosis associated with preterm delivery and postpartum abscess formation. Taiwan J Obstet Gynecol. 2016;55:620–2.

    Article  PubMed  Google Scholar 

  39. Al Jama FE. Management of adenomyosis in subfertile women and pregnancy outcome. Oman Med J. 2011;26:178–81.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Wang PH, Liu WM, Fuh JL, Cheng MH, Chao HT. Comparison of surgery alone and combined surgical-medical treatment in the management of symptomatic uterine adenomyoma. Fertil Steril. 2009;92:876–85.

    Article  CAS  PubMed  Google Scholar 

  41. Yamanaka A, Kimura F, Kishi Y, Takahashi K, Suginami H, Shimizu Y, Murakami T. Progesterone and synthetic progestin, dienogest, induce apoptosis of human primary cultures of adenomyotic stromal cells. Eur J Obstet Gynecol Reprod Biol. 2014;179:170–4.

    Article  CAS  PubMed  Google Scholar 

  42. Kishi Y, Yabuta M, Taniguchi F. Who will benefit from uterus-sparing surgery in adenomyosis-associated subfertility? Fertil Steril. 2014;102:802–807.e801.

    Article  PubMed  Google Scholar 

  43. Nishida M, Takano K, Arai Y, Ozone H, Ichikawa R. Conservative surgical management for diffuse uterine adenomyosis. Fertil Steril. 2010;94:715–9.

    Article  PubMed  Google Scholar 

  44. Osada H, Silber S, Kakinuma T, Nagaishi M, Kato K, Kato O. Surgical procedure to conserve the uterus for future pregnancy in patients suffering from massive adenomyosis. Reprod Biomed Online. 2011;22:94–9.

    Article  PubMed  Google Scholar 

  45. Fujishita A, Masuzaki H, Khan KN, Kitajima M, Ishimaru T. Modified reduction surgery for adenomyosis. A preliminary report of the transverse H incision technique. Gynecol Obstet Investig. 2004;57:132–8.

    Article  Google Scholar 

  46. Sun AJ, Luo M, Wang W, Chen R, Lang JH. Characteristics and efficacy of modified adenomyomectomy in the treatment of uterine adenomyoma. Chin Med J. 2011;124:1322–6.

    PubMed  Google Scholar 

  47. Takeuchi H, Kitade M, Kikuchi I, Shimanuki H, Kumakiri J, Kitano T, Kinoshita K. Laparoscopic adenomyomectomy and hysteroplasty: a novel method. J Minim Invasive Gynecol. 2006;13:150–4.

    Article  PubMed  Google Scholar 

  48. Nagao Y, Osato K, Kubo M, Kawamura T, Ikeda T, Yamawaki T. Spontaneous uterine rupture in the 35th week of gestation after laparoscopic adenomyomectomy. Int Med Case Rep J. 2016;9:1–4.

    PubMed  Google Scholar 

  49. Otsubo Y, Nishida M, Arai Y, Ichikawa R, Taneichi A, Sakanaka M. Association of uterine wall thickness with pregnancy outcome following uterine-sparing surgery for diffuse uterine adenomyosis. Aust N Z J Obstet Gynaecol. 2016;56:88–91.

    Article  PubMed  Google Scholar 

  50. Gui T, Chen C, Zhang Z, Tang W, Qian R, Ma X, Cao P, Wan G. The disturbance of TH17-Treg cell balance in adenomyosis. Fertil Steril. 2014;101:506–14.

    Article  CAS  PubMed  Google Scholar 

  51. Kunz G, Beil D, Huppert P, Noe M, Kissler S, Leyendecker G. Adenomyosis in endometriosis—prevalence and impact on fertility. Evidence from magnetic resonance imaging. Hum Reprod. 2005;20:2309–16.

    Article  CAS  PubMed  Google Scholar 

  52. Peric H, Fraser IS. The symptomatology of adenomyosis. Best Pract Res Clin Obstet Gynaecol. 2006;20:547–55.

    Article  CAS  PubMed  Google Scholar 

  53. Petraglia F, Arcuri F, de Ziegler D, Chapron C. Inflammation: a link between endometriosis and preterm birth. Fertil Steril. 2012;98:36–40.

    Article  PubMed  Google Scholar 

  54. Parazzini F, Tozzi L, Bianchi S. Pregnancy outcome and uterine fibroids. Best Pract Res Clin Obstet Gynaecol. 2016;34:74–84.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan

    Hiroshi Tamura M.D., Ph.D. & Norihiro Sugino M.D., Ph.D.

Authors
  1. Hiroshi Tamura M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Norihiro Sugino M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hiroshi Tamura M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan

    Norihiro Sugino

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Tamura, H., Sugino, N. (2018). Pregnancy Complications in Women with Adenomyosis. In: Sugino, N. (eds) Uterine Fibroids and Adenomyosis. Comprehensive Gynecology and Obstetrics. Springer, Singapore. https://doi.org/10.1007/978-981-10-7167-6_12

Download citation

  • DOI: https://doi.org/10.1007/978-981-10-7167-6_12

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-7166-9

  • Online ISBN: 978-981-10-7167-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation