Locoregional and Palliative Therapies for Patients with Unresectable Peritoneal Metastases

  • Ninad Katdare
  • Robin Prabhu
  • Aditi Bhatt


A large proportion of patients with peritoneal metastases (PM) are excluded from potentially curative treatment with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) due to their disease extent and distribution, site of primary tumor, or their general condition which precludes an aggressive surgical effort. Some of these patients are symptomatic from their PM, and in them, the management of symptoms which severely impair the quality of life takes precedence over other treatment goals. In asymptomatic patients, the scientific and surgical community is working to develop and implement new systemic and locoregional therapies that could increase the survival over systemic therapies alone and prevent the development of symptoms. Some of these are being used in a neoadjuvant manner to downstage the disease and make patients eligible for CRS and HIPEC. Patients with unresectable PM fall in between palliation and cure from the treatment point of view. A multidisciplinary approach keeping in mind the goals of therapy which are based on the disease status and expectations of the patient and their caregivers should be used to treat these patients.


Unresectable peritoneal metastases Palliative treatment PIPAC Malignant bowel obstruction 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Department of Surgical OncologySL Raheja HospitalMumbaiIndia
  2. 2.Department of Surgical OncologyFortis HospitalBangaloreIndia

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