Abstract
Developing and marketing vitamin rich food products are major challenge because of efficient nutritional delivery system, longer stability, and shelf life. Nanoemulsified and nanoencapsulated vitamin based nanoemulsions have been developed to overcome these issues. Recently, vitamin based nanoemulsions have been developed and also been marketed. Here in this review, (i) several vitamin enriched nanoemulsions have been discussed in which different oils have been used to meet specific need (ii) the opportunities of such products in markets and research have been discussed; (iii) the conventional nanoemulsion characterization techniques have been discussed and also (iv) non-conventional and newly developed characterization techniques have been discussed to show their future and impact on nanoemulsion characterization.
References
Ahmad J, Mir SR, Kohli K et al (2014) Solid-nanoemulsion preconcentrate for oral delivery of paclitaxel: formulation design, biodistribution, and γ scintigraphy imaging. Biomed Res Int. https://doi.org/10.1155/2014/984756
Alaimo D, Hermida Merino D, Grignard B et al (2015) Small-angle X-ray scattering insights into the architecture-dependent emulsifying properties of amphiphilic copolymers in supercritical carbon dioxide. J Phys Chem B 119:1706–1716. https://doi.org/10.1021/jp5086558
Attia MF, Anton N, Bouchaala R et al (2015) Functionalization of nano-emulsions with an amino-silica shell at the oil-water interface. RSC Adv 5:74353–74361. https://doi.org/10.1039/c5ra12676b
Azeem A, Rizwan M, Ahmad FJ et al (2009) Nanoemulsion components screening and selection: a technical note. AAPS PharmSciTech 10:69–76. https://doi.org/10.1208/s12249-008-9178-x
Bae P, Chung B (2014) Multiplexed detection of various breast cancer cells by perfluorocarbon/quantum dot nanoemulsions conjugated with antibodies. Nano Converg 1:23. https://doi.org/10.1186/s40580-014-0023-5
Berkeley Labs (2016) Tiny bubbles hold big promise for NMR/MRI. Tiny bubbles hold big promise for NMR/MRI. Accessed 19 Jun 2016
Bromley PJ (2011) Nanoemulsion including sucrose fatty acid ester
Choi S, Kim JW, Lee YJ et al (2014) Evaluation of transdermal delivery of nanoemulsions in ex vivo porcine skin using two-photon microscopy and confocal laser-scanning microscopy. J Biomed Opt 19:106006
Costa JA, Farias NC, Queirós YGC, Mansur CRE (2013) Determination of oil-in-water using nanoemulsions as solvents and UV visible and total organic carbon detection methods. Talanta 107:304–311. https://doi.org/10.1016/j.talanta.2013.01.040
Da Costa S, Basri M, Shamsudin N, Basri H (2014) Stability of positively charged nanoemulsion formulation containing steroidal drug for effective transdermal application. J Chem. https://doi.org/10.1155/2014/748680
Dasgupta S, Ghosh SK, Ray S et al (2014) In vitro & in vivo studies on lornoxicam loaded nanoemulsion gels for topical application. Curr Drug Deliv 11:132–138. https://doi.org/10.2174/15672018113106660063
Dasgupta N, Ranjan S, Mundekkad D et al (2015) Nanotechnology in agro-food: from field to plate. Food Res Int 69:381–400. https://doi.org/10.1016/j.foodres.2015.01.005
Dasgupta N, Ranjan S, Chakraborty AR et al (2016) Nanoagriculture and water quality management. In: Ranjan S, Nandita D, Lichtfouse E (eds) Nanoscience in food and agriculture 1. Springer, Berlin/Heidelberg
Esposito E, Ravani L, Drechsler M et al (2015) Cannabinoid antagonist in nanostructured lipid carriers (NLCs): design, characterization and in vivo study. Mater Sci Eng C Mater Biol Appl 48:328–336. https://doi.org/10.1016/j.msec.2014.12.012
Fielding LA, Mykhaylyk OO, Armes SP et al (2012) Correcting for a density distribution: particle size analysis of core-shell nanocomposite particles using disk centrifuge photosedimentometry. Langmuir 28:2536–2544. https://doi.org/10.1021/la204841n
Filipović J, Pezo L, Filipović V et al (2015) The effects of ω-3 fatty acids and inulin addition to spelt pasta quality. LWT-Food Sci Technol 63:43–51
Fissan H, Ristig S, Kaminski H et al (2014) Comparison of different characterization methods for nanoparticle dispersions before and after aerosolization. Anal Methods 6:7324. https://doi.org/10.1039/C4AY01203H
Ghosh V, Mukherjee A, Chandrasekaran N (2013) Ultrasonic emulsification of food-grade nanoemulsion formulation and evaluation of its bactericidal activity. Ultrason Sonochem 20:338–344. https://doi.org/10.1016/j.ultsonch.2012.08.010
Gordon V, Marom G, Magdassi S (2015) Formation of hydrophilic nanofibers from nanoemulsions through electrospinning. Int J Pharm 478:172–179. https://doi.org/10.1016/j.ijpharm.2014.11.038
Grapentin C, Temme S, Mayenfels F, et al (2014) Optimization of perfluorocarbon nanoemulsions for molecular imaging by 19F MRI
Grapentin C, Barnert S, Schubert R (2015) Monitoring the stability of perfluorocarbon nanoemulsions by Cryo-TEM image analysis and dynamic light scattering. PLoS One 10:e0130674
Guttoff M, Saberi AH, Mcclements DJ (2015) Formation of vitamin D nanoemulsion-based delivery systems by spontaneous emulsification: factors affecting particle size and stability. Food Chem 171:117–122. https://doi.org/10.1016/j.foodchem.2014.08.087
Hategekimana J, Chamba MVM, Shoemaker CF et al (2015) Vitamin E nanoemulsions by emulsion phase inversion: effect of environmental stress and long-term storage on stability and degradation in different carrier oil types. Colloids Surf A Physicochem Eng Asp 483:70–80. https://doi.org/10.1016/j.colsurfa.2015.03.020
Hoscheid J, Outuki PM, Kleinubing SA et al (2015) Development and characterization of Pterodon pubescens oil nanoemulsions as a possible delivery system for the treatment of rheumatoid arthritis. Colloids Surf A Physicochem Eng Asp 484:19–27
Jain A, Shivendu R, Nandita D, Ramalingam C (2016) Nanomaterials in food and agriculture: an overview on their safety concerns and regulatory issues. Crit Rev Food Sci Nutr. https://doi.org/10.1080/10408398.2016.1160363
Jaiswal M, Dudhe R, Sharma PK (2015) Nanoemulsion: an advanced mode of drug delivery system. 3 Biotech 5:123–127
Janjic JM, Ahrens ET (2009) Fluorine-containing nanoemulsions for MRI cell tracking. Wiley Interdiscip Rev Nanomed Nanobiotechnol 1:492–501
Janjic JM, Srinivas M, Kadayakkara DKK, Ahrens ET (2008) Self-delivering nanoemulsions for dual fluorine-19 MRI and fluorescence detection. J Am Chem Soc 130:2832–2841. doi:https://doi.org/10.1021/ja077388j
Janjic J, Kadayakkara D, Pusateri L, Ahrens E (2009) Novel perfluorocarbon nanoemulsion for 19F MRI cell tracking of two cell populations in vivo. In: Proceedings 17th Scientific Meeting, International Society for Magnetic Resonance in Medicine, p 3134
Jenning V, Thünemann a F, Gohla SH (2000) Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids. Int J Pharm 199:167–177
Kabalnov AS, Shchukin ED (1992) Ostwald ripening theory: applications to fluorocarbon emulsion stability. Adv Colloid Interf Sci 38:69–97. https://doi.org/10.1016/0001-8686(92)80043-W
Klang V, Matsko NB, Valenta C, Hofer F (2012) Electron microscopy of nanoemulsions: an essential tool for characterisation and stability assessment. Micron 43:85–103
Komaiko J, McClements DJ (2014) Low-energy formation of edible nanoemulsions by spontaneous emulsification: factors influencing particle size. J Food Eng 146:122–128. https://doi.org/10.1016/j.jfoodeng.2014.09.003
Komaiko J, McClements DJ (2015) Food-grade nanoemulsion filled hydrogels formed by spontaneous emulsification and gelation: optical properties, rheology, and stability. Food Hydrocoll 46:67–75. https://doi.org/10.1016/j.foodhyd.2014.12.031
Laouini A, Fessi H, Charcosset C (2012) Membrane emulsification: a promising alternative for vitamin E encapsulation within nano-emulsion. J Membr Sci 423–424:85–96. https://doi.org/10.1016/j.memsci.2012.07.031
Lee HS, Morrison ED, Zhang Q, McCormick AV (2016) Cryogenic transmission electron microscopy study: preparation of vesicular dispersions by quenching microemulsions. J Microsc 263:293
Li Y, Teng Z, Chen P et al (2015) Enhancement of aqueous stability of allyl isothiocyanate using nanoemulsions prepared by an emulsion inversion point method. J Colloid Interface Sci 438:130–137. https://doi.org/10.1016/j.jcis.2014.09.055
Liuzzi R, Carciati A, Guido S, Caserta S (2016) Transport efficiency in transdermal drug delivery: what is the role of fluid microstructure? Colloids Surf B Biointerfaces 139:294–305
Lucca LG, de Matos SP, Borille BT et al (2015) Determination of β-caryophyllene skin permeation/retention from crude copaiba oil (Copaifera multijuga Hayne) and respective oil-based nanoemulsion using a novel HS-GC/MS method. J Pharm Biomed Anal 104:144–148. https://doi.org/10.1016/j.jpba.2014.11.013
Ma Q, Davidson PM, Zhong Q (2016) Nanoemulsions of thymol and eugenol co-emulsified by lauric arginate and lecithin. Food Chem 206:167–173. https://doi.org/10.1016/j.foodchem.2016.03.065
Mahendran V, Philip J (2013) Sensing of biologically important cations such as Na+, K +, Ca2+, Cu2+, and Fe3+ using magnetic nanoemulsions. Langmuir 29:4252–4258. https://doi.org/10.1021/la400502b
Maher PG, Roos YH, Kilcawley KN et al (2015) Levels of pentanal and hexanal in spray dried nanoemulsions. LWT Food Sci Technol 63:1069–1075. https://doi.org/10.1016/j.lwt.2015.04.044
Makidon PE, Bielinska AU, Nigavekar SS et al (2008) Pre-clinical evaluation of a novel nanoemulsion-based hepatitis B mucosal vaccine. PLoS One. https://doi.org/10.1371/journal.pone.0002954
Martins JT, Ramos Óscar L, Pinheiro AC et al (2015) Edible bio-based nanostructures: delivery, absorption and potential toxicity. Food Eng Rev 7:491–513
Mayer S, Weiss J, McClements DJ (2013) Vitamin E-enriched nanoemulsions formed by emulsion phase inversion: factors influencing droplet size and stability. J Colloid Interface Sci 402:122–130. https://doi.org/10.1016/j.jcis.2013.04.016
Mehmood T (2015) Optimization of the canola oil based vitamin E nanoemulsions stabilized by food grade mixed surfactants using response surface methodology. Food Chem 183:1–7. https://doi.org/10.1016/j.foodchem.2015.03.021
Middelberg APJ, Zeng B (2013) Nanoemulsions
Morais DJM, Burgess J (2014a) Vitamin E nanoemulsions characterization and analysis. Int J Pharm 465:455–463. https://doi.org/10.1016/j.ijpharm.2014.02.034
Morais JM, Burgess DJ (2014b) In vitro release testing methods for vitamin E nanoemulsions. Int J Pharm 475:393–400
Nandita D, Ranjan S, Mundra S et al (2015) Fabrication of food grade vitamin E nanoemulsion by low energy approach, characterization and its application. Int J Food Prop. https://doi.org/10.1080/10942912.2015.1042587
Nandita D, Ranjan S, Mundra S et al (2016) Fabrication of food grade vitamin E nanoemulsion by low energy approach, characterization and its application. Int J Food Prop 19:700–708. https://doi.org/10.1080/10942912.2015.1042587
Neeru S, Saurabh Manaswita V, Sandeep Kumar S, Priya Ranjan Prasad V (2014) Consequences of lipidic nanoemulsions on membrane integrity and ultrastructural morphology of Staphylococcus aureus. Mater Res Express 1:25401. https://doi.org/10.1088/2053-1591/1/2/025401
Ozturk B, Argin S, Ozilgen M, McClements DJ (2014) Formation and stabilization of nanoemulsion-based vitamin E delivery systems using natural surfactants: quillaja saponin and lecithin. J Food Eng 142:57–63
Ozturk B, Argin S, Ozilgen M, McClements DJ (2015a) Formation and stabilization of nanoemulsion-based vitamin E delivery systems using natural biopolymers: whey protein isolate and gum Arabic. Food Chem. https://doi.org/10.1016/j.foodchem.2015.05.005
Ozturk B, Argin S, Ozilgen M, McClements DJ (2015b) Nanoemulsion delivery systems for oil-soluble vitamins: influence of carrier oil type on lipid digestion and vitamin D3 bioaccessibility. Food Chem 187:499–506. https://doi.org/10.1016/j.foodchem.2015.04.065
Pan K, Zhong Q (2016) Organic nanoparticles in foods: fabrication, characterization, and utilization. Annu Rev Food Sci Technol 7:245–266
Panatieri LF, Brazil NT, Faber K et al (2016) Nanoemulsions containing a coumarin-rich extract from pterocaulon balansae (Asteraceae) for the treatment of ocular acanthamoeba keratitis. AAPS PharmSciTech:1–8
Patel SK, Williams J, Janjic JM (2013) Cell labeling for 19F MRI: new and improved approach to perfluorocarbon nanoemulsion design. Biosensors 3:341–359. https://doi.org/10.3390/bios3030341
Pathan IB, Mallikarjuna Setty C (2011) Enhancement of transdermal delivery of tamoxifen citrate using nanoemulsion vehicle. Int J PharmTech Res 3:287–297
Pathan IB, Mallikarjuna Setty C (2012) Nanoemulsion system for transdermal delivery of tamoxifen citrate: design, characterization, effect of penetration enhancers and in vivo studies. Dig J Nanomater Biostruct 7:1373–1387
Pawar VK, Panchal SB, Singh Y et al (2014) Immunotherapeutic vitamin e nanoemulsion synergies the antiproliferative activity of paclitaxel in breast cancer cells via modulating Th1 and Th2 immune response. J Control Release 196:295–306. https://doi.org/10.1016/j.jconrel.2014.10.010
Rachmawati H, Budiputra DK, Mauludin R (2014) Curcumin nanoemulsion for transdermal application: formulation and evaluation. Drug Dev Ind Pharm 9045:560–566. https://doi.org/10.3109/03639045.2014.884127
Rajpoot P, Pathak K, Bali V (2011) Therapeutic applications of nanoemulsion based drug delivery systems: a review of patents in last two decades. Recent Pat Drug Deliv Formul 5:163–172. https://doi.org/10.2174/187221111795471427
Ranjan S, Dasgupta N, Chakraborty AR et al (2014) Nanoscience and nanotechnologies in food industries: opportunities and research trends. J Nanopart Res 16:1–23. https://doi.org/10.1007/s11051-014-2464-5
Ranjan S, Nandita D, Lichtfouse E (2016a) Nanoscience in food and agriculture 1, 1st edn. Springer International Publishing, Cham
Ranjan S, Nandita D, Lichtfouse E (2016b) Nanoscience in food and agriculture 2, 1st edn. Springer International Publishing, Cham
Saberi AH, Fang Y, McClements DJ (2013) Effect of glycerol on formation, stability, and properties of vitamin-E enriched nanoemulsions produced using spontaneous emulsification. J Colloid Interface Sci 411:105–113. https://doi.org/10.1016/j.jcis.2013.08.041
Saifullah M, Ahsan A, Shishir MRI (2016) Production stability and applications of micro- and nano-emulsion in food processing industry. In: Grumezescu A (ed) Emulsions, 1st edn. Academic Press, London, pp 405–433
Salvia-Trujillo L, Rojas-Graü MA, Soliva-Fortuny R, Martín-Belloso O (2013) Effect of processing parameters on physicochemical characteristics of microfluidized lemongrass essential oil-alginate nanoemulsions. Food Hydrocoll 30:401–407. https://doi.org/10.1016/j.foodhyd.2012.07.004
Sari TP, Mann B, Kumar R et al (2015) Preparation and characterization of nanoemulsion encapsulating curcumin. Food Hydrocoll 43:540–546. https://doi.org/10.1016/j.foodhyd.2014.07.011
Schroder L (2013) Xenon for NMR biosensing – inert but alert. Phys Med 29:3–16
Shakeel F, Baboota S, Ahuja A et al (2008) Skin permeation mechanism of aceclofenac using novel nanoemulsion formulation. Pharmazie 63:580–584. https://doi.org/10.1691/ph.2008.8036
Shakeel F, Shafiq S, Haq N et al (2012) Nanoemulsions as potential vehicles for transdermal and dermal delivery of hydrophobic compounds: an overview. Expert Opin Drug Deliv 9:953–974
Shams K, Ahi H (2013) Synthesis of 5A zeolite nanocrystals using kaolin via nanoemulsion- ultrasonic technique and study of its sorption using a known kerosene cut. Microporous Mesoporous Mater 180:61–71. https://doi.org/10.1016/j.micromeso.2013.06.019
Singh N, Verma SM, Singh SK et al (2015a) Antibacterial activity of cationised and non-cationised placebo lipidic nanoemulsion using transmission electron microscopy. J Exp Nanosci 10:299–309. https://doi.org/10.1080/17458080.2013.830199
Singh N, Verma SM, Singh SK, Verma PRP (2015b) Antibacterial action of lipidic nanoemulsions using atomic force microscopy and scanning electron microscopy on Escherichia coli. J Exp Nanosci 10:381–391
Soltani S, Zakeri-Milani P, Barzegar-Jalali M, Jelvehgari M (2016) Design of eudragit RL nanoparticles by nanoemulsion method as carriers for ophthalmic drug delivery of ketotifen fumarate. Iran J Basic Med Sci 19:850–860
Song Z, Sun H, Yang Y et al (2016) Enhanced efficacy and anti-biofilm activity of novel nanoemulsions against skin burn wound multi-drug resistant MRSA infections. Nanomed Nanotechnol Biol Med 12:1543–1555
Stevens TK, Ramirez RM, Pines A (2013) Nanoemulsion contrast agents with sub-picomolar sensitivity for xenon NMR. J Am Chem Soc 135:9576–9579. https://doi.org/10.1021/ja402885q
Sugumar S, Mukherjee A, Chandrasekaran N (2015) Eucalyptus oil nanoemulsion-impregnated chitosan film: antibacterial effects against a clinical pathogen, Staphylococcus aureus, in vitro. Int J Nanomedicine 10:67–75. https://doi.org/10.2147/IJN.S79982
Swarnalatha S, Selvi PK, Ganesh Kumar A, Sekaran G (2008) Nanoemulsion drug delivery by ketene based polyester synthesized using electron rich carbon/silica composite surface. Colloids Surf B Biointerfaces 65:292–299. https://doi.org/10.1016/j.colsurfb.2008.04.012
Tabibiazar M, Davaran S, Hashemi M et al (2015) Design and fabrication of a food-grade albumin-stabilized nanoemulsion. Food Hydrocoll 44:220–228
Takegami S, Katsumi H, Asai K et al (2015) Application of 19F NMR spectroscopy using a novel a-tocopherol derivative as a 19F NMR probe for a pharmacokinetic study of lipid nano-emulsions in mice. Pharm Anal Acta 6:2
Truong T, Morgan GP, Bansal N et al (2015) Crystal structures and morphologies of fractionated milk fat in nanoemulsions. Food Chem 171:157–167. https://doi.org/10.1016/j.foodchem.2014.08.113
Tsai M-J, Y-S F, Lin Y-H et al (2014) The effect of nanoemulsion as a carrier of hydrophilic compound for transdermal delivery. PLoS One 9:e102850
Uzun S, Kim H, Leal C, Padua GW (2016) Ethanol-induced whey protein gels as carriers for lutein droplets. Food Hydrocoll 61:426–432
Vezocnik V, Rebolj K, Sitar S et al (2015) Size fractionation and size characterization of nanoemulsions of lipid droplets and large unilamellar lipid vesicles by asymmetric-flow field-flow fractionation/multi-angle light scattering and dynamic light scattering. J Chromatogr A 1418:185–191. https://doi.org/10.1016/j.chroma.2015.09.048
Yoshida K, Sekine T, Matsuzaki F et al (1999) Stability of vitamin A in oil-in-water-in-oil-type multiple emulsions. J Am Oil Chem Soc 76:1–6. https://doi.org/10.1007/s11746-999-0212-2
Youssof AME, Salem-Bekhit MM, Shakeel F et al (2016) Analysis of anti-neoplastic drug in bacterial ghost matrix, w/o/w double nanoemulsion and w/o nanoemulsion by a validated “green” liquid chromatographic method. Talanta 154:292–298
Zhang A, Wu D, Liu F, Zhang F (2007) Preparation of plasmid nanoemulsion and its character determination by anion exchange chromatography method. Sheng Wu Gong Cheng Xue Bao 23:1135–1139
Zhou K, Zhang QG, Li HM et al (2014) Ultrathin cellulose nanosheet membranes for superfast separation of oil-in-water nanoemulsions. Nanoscale 6:10363–10369. https://doi.org/10.1039/c4nr03227f
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Dasgupta, N., Ranjan, S. (2018). Research Updates on Different Vitamins Based Nanoemulsions and Characterization of Nanoemulsions. In: An Introduction to Food Grade Nanoemulsions. Environmental Chemistry for a Sustainable World. Springer, Singapore. https://doi.org/10.1007/978-981-10-6986-4_6
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