Diagnosing and managing many ophthalmic diseases begins with the pupil. Pupil testing would enable you to make a right direction when you met many neuro-ophthalmic conditions. Actually, pupil reflex in response to light stimulus is composed of afferent fibers from the retina to the Edinger-Westphal (EW) nucleus of the oculomotor nucleus and efferent fibers from the EW nucleus to the pupillary sphincter. The afferent fibers travel through the retina, optic nerve, optic chiasm, and optic radiation and are separated before lateral geniculate nucleus and connected to EW nucleus in the dorsomedial side of the oculomotor nucleus complex.
- Bell RA, Thompson HS. Optic tract lesions and relative afferent pupillary defect. In: Thompson HS, editor. Topics in neuro-ophthalmology. Baltimore: Williams and Wilkins; 1979. p. 164–5.Google Scholar