Okra Gum Based Multiple Units for Oral Drug Delivery

  • Amit Kumar NayakEmail author
  • Md Saquib Hasnain
Part of the SpringerBriefs in Applied Sciences and Technology book series (BRIEFSAPPLSCIENCES)


OG is obtained from the fruits of okra plant (Hibiscus esculentus, family: Malvaceae) (Hirose et al. in Carbohydr Polym 339:9–19, 2004). This plant is cultivated in the tropical/subtropical areas around the world. OG contains L-galacturonic acid, D-galactose as well as L-rhamnose, (Mishra et al. in Carbohydr Polym 72:608–615, 2008; Sinha et al. in Int J Biol Macromol 79, 555–563, 2015a).


  1. K. Ameena, C. Dilip, R. Saraswathi, P.N. Krishnan, C. Sankar, S.P. Simi, Isolation of the mucilages from Hibiscus rosasinensis linn. and Okra (Abelmoschusesculentus linn.) and studies of the binding effects of the mucilages. Asian Pac. J. Trop. Med. 3, 539–543 (2010)CrossRefGoogle Scholar
  2. M.O. Emeje, C.Y. Isimi, O.O. Kunle, Evaluation of okra gum as a dry binder in paracetamol tablet formulations. Cont. J. Pharm. Sci. 1, 15–22 (2007)Google Scholar
  3. K. Hirose, K. Endo, K. Hasegawa, A convenient synthesis of lepidimoide from okra mucilage and its growth-promoting activity in hypocotyls. Carbohydr. Polym. 339, 9–19 (2004)CrossRefGoogle Scholar
  4. V.D. Kalu, M.A. Odeniyi, K.T. Jaiyeoba, Matrix properties of a new plant gum in controlled drug delivery. Arch. Pharmacal Res. 30, 884–889 (2007)CrossRefGoogle Scholar
  5. A. Mishra, J.H. Clark, S. Pal, Modification of Okra mucilage with acrylamide: synthesis, characterization and swelling behavior. Carbohydr. Polym. 72, 608–615 (2008)CrossRefGoogle Scholar
  6. A.K. Nayak, T.J. Ara, M.S. Hasnain, N. Hoda, Okra gum-alginate composites for controlled releasing drug delivery, in Applications of Nanocomposite materials in drug delivery, ed. A.A.M. Inamuddin, A.A. Mohammad. volume in (Woodhead Publishing Series in Biomaterials, Elsevier Inc., 2018), pp. 761–785Google Scholar
  7. I. Ogaji, Some physicochemical properties of acetaminophen pediatric suspensions formulated with okra gums obtained from different extraction process as suspending agent. Asian J. Pharm. 5, 15–20 (2011)CrossRefGoogle Scholar
  8. I. Ogaji, O. Nnoli, Film coating potential of okra gum using paracetamol as a model drug. Asian J. Pharm. 4, 130–134 (2014)CrossRefGoogle Scholar
  9. I.J. Ogaji, S.W. Hoag, Novel extraction and application of okra gum as a film coating agent using theophylline as a model drug. J. Adv. Pharm. Technol. Res. 5, 70–77 (2014)CrossRefGoogle Scholar
  10. V.I. Patel, H.A. Patel, M. Jani, A. Shah, S. Kumar, J.A. Patel, Formulation and evaluation of okra fruit mucilage as a binder in paracetamol and ibuprofen tablet. Int. J. Pharm. Res. Sci. 1, 156–161 (2012)Google Scholar
  11. P. Sinha, U. Ubaidulla, M.S. Hasnain, A.K. Nayak, B. Rama, Alginate-okra gum blend beads of diclofenac sodium from aqueous template using ZnSO4 as a cross-linker. Int. J. Biol. Macromol. 79, 555–563 (2015a)CrossRefGoogle Scholar
  12. P. Sinha, U. Ubaidulla, A.K. Nayak, Okra (Hibiscus esculentus) gum-alginate blend mucoadhesive beads for controlled glibenclamide release. Int. J. Biol. Macromol. 72, 1069–1075 (2015b)CrossRefGoogle Scholar
  13. N.D. Zaharuddin, MI Noordin, A. Kadivar(2014) The use of Hibiscus esculentus (Okra) gum in sustaining the release of propranolol hydrochloride in a solid oral dosage form. BioMed. Res. Int. 2014, Article ID 735891Google Scholar

Copyright information

© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of PharmaceuticsSeemanta Institute of Pharmaceutical SciencesMayurbhanjIndia
  2. 2.Department of PharmacyShri Venkateshwara UniversityAmrohaIndia

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