Plant Polysaccharides in Drug Delivery Applications

  • Amit Kumar NayakEmail author
  • Md Saquib Hasnain
Part of the SpringerBriefs in Applied Sciences and Technology book series (BRIEFSAPPLSCIENCES)


Nowadays, the entire world is moving en route for the utilization of natural excipients in diverse biomedical applications (Hasnain et al. in Sci J UBU 1:1–13, 2010; Mano et al. in J R Soc Interf 4:999–1030, 2007; Nayak in Pharmaceut Sci 2:1–5, 2010; Nayak and Pal in Everyman’s Sci XLVI, 347–352, 2012, Nayak and Pal in Natural starches-blended ionotropically gelled microparticles/beads for sustained drug release. Wiley-Scrivener, USA, pp. 527–560, 2017a).


  1. A.M. Avachat, R.R. Dash, S.N. Shrotriya, Recent investigations of plant based natural gums, mucilages and resins in novel drug delivery systems. Indian J Pharm Educ Res 45, 86–99 (2011)Google Scholar
  2. C.E. Beneke, A.M. Viljoen, J.H. Hamman, Polymeric plant-derived excipients in drug delivery. Molecules 14, 2602–2620 (2009)CrossRefGoogle Scholar
  3. M.S. Hasnain, A.K. Nayak, R. Singh, F. Ahmad, Emerging trends of natural-based polymeric systems for drug delivery in tissue engineering applications. Sci. J. UBU 1, 1–13 (2010)Google Scholar
  4. M.S. Hasnain, A.K. Nayak, Chitosan as responsive polymer for drug delivery applications, in Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications, Volume 1, Types and Triggers, ed. A.S.H. Makhlouf, N.Y. Abu-Thabit (Woodhead Publishing Series in Biomaterials, Elsevier Ltd., 2018b), pp. 581–605Google Scholar
  5. M. Hati, B.K. Jena, S. Kar, A.K. Nayak, Evaluation of anti-inflammatory and anti-pyretic activity of Carissa carandas L. leaf extract in rats. J. Pharm. Chem. Biol. Sci. 1, 18–25 (2014)Google Scholar
  6. B.K. Jena, B. Ratha, S. Kar, S. Mohanta, A.K. Nayak, Antibacterial activity of the ethanol extract of Ziziphus xylopyrus Willd. (Rhamnaceae). Int. J. Pharma Res. Rev. 1, 46–50 (2012a)Google Scholar
  7. B.K. Jena, B. Ratha, S. Kar, S. Mohanta, M. Tripathy, A.K. Nayak, Wound healing potential of Ziziphus xylopyrus Willd. (Rhamnaceae) stem bark ethanol extract using in vitro and in vivo model. J. Drug Deliv. Therapeut. 2, 41–46 (2012b)Google Scholar
  8. P.B. Malafaya, G.A. Silva, R.L. Reis, Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. Adv. Drug Deliv. Rev. 59, 207–233 (2007)CrossRefGoogle Scholar
  9. J.F. Mano, G.A. Silva, H.S. Azevedo, P.B. Malafaya, R.A. Sousa, S.S. Silva, L.F. Boesel, J.M. Oliveira, T.C. Santos, A.P. Marques, N.M. Neves, R.L. Reis, Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends. J. R. Soc. Interf. 4, 999–1030 (2007)CrossRefGoogle Scholar
  10. A.K. Nayak, Advances in therapeutic protein production and delivery. Int. J. Pharm. Pharmaceut. Sci. 2, 1–5 (2010)Google Scholar
  11. A.K. Nayak, D. Pal (2012) Natural polysaccharides for drug delivery in tissue engineering. Everyman’s Sci XLVI, 347–352Google Scholar
  12. A.K. Nayak, D. Pal, K. Santra, Screening of polysaccharides from tamarind, fenugreek and jackfruit seeds as pharmaceutical excipients. Int. J. Biol. Macromol. 79, 756–760 (2015)CrossRefGoogle Scholar
  13. A.K. Nayak, D. Pal, Natural starches-blended ionotropically-gelled micrparticles/beads for sustained drug release, in Handbook of composites from renewable materials, ed. V.K. Thakur, M.K. Thakur, M.R. Kessler, Volume 8, Nanocomposites: Advanced Applications (Wiley-Scrivener, USA, 2017a), pp. 527–560Google Scholar
  14. A.K. Nayak, D. Pal, Tamarind seed polysaccharide: an emerging excipient for pharmaceutical use. Indian J. Pharm. Educ. Res. 51, S136-S146 (2017b)Google Scholar
  15. A.K. Nayak, D. Pal, D.R. Pany, B. Mohanty, Evaluation of Spinacia oleracea L. leaves mucilage as innovative suspending agent. J. Adv. Pharm. Technol. Res. 1, 338–341 (2010)CrossRefGoogle Scholar
  16. A.K. Nayak, D. Pal, Functionalization of tamarind gum for drug delivery, in: Functional biopolymers, ed. V.K. Thakur, M.K. Thakur (Springer International Publishing, Switzerland, 2018), pp. 35–56Google Scholar
  17. A.K. Nayak, H. Bera, M.S. Hasnain, D. Pal, Graft-copolymerization of plant polysaccharides, in: Biopolymer grafting, synthesis and properties, ed. V.K. Thakur (Elsevier Inc., 2018a), pp. 1–62Google Scholar
  18. A.K. Nayak, M.S. Hasnain, D. Pal, Gelled microparticles/beads of sterculia gum and tamarind gum for sustained drug release, in Handbook of springer on polymeric gel, ed. V.K. Thakur, M.K. Thakur (Springer International Publishing, Switzerland, 2018b), pp. 361–414Google Scholar
  19. D. Pal, A.K. Nayak, S. Kalia, Studies on Basella alba L. leaves mucilage: evaluation of suspending properties. Int. J. Drug Discov. Technol. 1, 15–20 (2010)Google Scholar
  20. D. Pal, A.K. Nayak, Alginates, blends and microspheres: controlled drug delivery, in Encyclopedia of biomedical polymers and polymeric biomaterials, ed. M. Mishra (Taylor & Francis Group, New York, NY 10017, U.S.A., Vol. I, 2015a), pp. 89–98Google Scholar
  21. D. Pal, A.K. Nayak, Interpenetrating polymer networks (IPNs): natural polymeric blends for drug delivery, in: Encyclopedia of biomedical polymers and polymeric biomaterials, ed. M. Mishra (Taylor & Francis Group, New York, NY 10017, U.S.A., Vol. VI, 2015b), pp. 4120–4130Google Scholar
  22. D. Pal, A.K. Nayak, Plant polysaccharides-blended ionotropically-gelled alginate multiple-unit systems for sustained drug release, in Handbook of composites from renewable materials, Volume 6, polymeric composites, ed. V.K. Thakur, M.K. Thakur, M.R. Kessler (Wiley-Scrivener, USA, 2017), pp. 399–400Google Scholar
  23. S. Sinha Mahapatra, S. Mohanta, A.K. Nayak, Preliminary investigation on angiogenic potential of Ziziphus oenoplia M. root ethanolic extract by chorioallantoic membrane model. Sci. Asia 37, 72–74 (2011)CrossRefGoogle Scholar

Copyright information

© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  1. 1.Department of PharmaceuticsSeemanta Institute of Pharmaceutical SciencesMayurbhanjIndia
  2. 2.Department of PharmacyShri Venkateshwara UniversityAmrohaIndia

Personalised recommendations