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Diagnosis of Superficial Esophageal Neoplasia: Classification

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Endoscopy in Early Gastrointestinal Cancers, Volume 1

Abstract

Esophageal cancer consistently ranks amongst the top ten cancer killers in the world and appears to be increasing in incidence. There are mainly two histology subtypes of esophageal cancer, derived either from squamous or glandular epithelium of the esophagus. Although they have different biological behaviors and contributing factors, both of these can be diagnosed by endoscopy imaging at an early stage. In order to maximize the chances for cure, a thorough and precise diagnosis of superficial neoplasia is of utmost importance. Several methods have been studied in advanced endoscopy imaging in order to obtain more accurate real-time diagnosis of premalignant and malignant changes in the esophagus. These include the use of vital stains and virtual chromoendoscopy. Improvement in endoscopic technologies over the past 2 decades has led to a massive deluge and development of various endoscopic classifications. In this chapter, we will summarize the application of advanced imaging modalities in the diagnosis of superficial esophageal neoplasia specifically concentrating on squamous cell carcinoma.

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References

  1. Organization WH. GLOBOCAN 2012: Estimated cancer incidence, mortality and prevalence worldwide in 2012. http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx. Accessed 20/08/2018.

  2. Wong MCS, Hamilton W, Whiteman DC, Jiang JY, Qiao Y, Fung FDH, et al. Global incidence and mortality of oesophageal cancer and their correlation with socioeconomic indicators temporal patterns and trends in 41 countries. Sci Rep. 2018;8(1):4522. https://doi.org/10.1038/s41598-018-19819-8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Weusten B, Bisschops R, Coron E, Dinis-Ribeiro M, Dumonceau JM, Esteban JM, et al. Endoscopic management of Barrett’s esophagus: European Society of Gastrointestinal Endoscopy (ESGE) position statement. Endoscopy. 2017;49(2):191–8. https://doi.org/10.1055/s-0042-122140.

    Article  PubMed  Google Scholar 

  4. Thosani N, Abu Dayyeh BK, Sharma P, Aslanian HR, Enestvedt BK, Komanduri S, et al. ASGE technology committee systematic review and meta-analysis assessing the ASGE preservation and incorporation of valuable endoscopic innovations thresholds for adopting real-time imaging-assisted endoscopic targeted biopsy during endoscopic surveillance of Barrett’s esophagus. Gastrointest Endosc. 2016;83(4):684–98e7. https://doi.org/10.1016/j.gie.2016.01.007.

    Article  PubMed  Google Scholar 

  5. Whiteman DC, Appleyard M, Bahin FF, Bobryshev YV, Bourke MJ, Brown I, et al. Australian clinical practice guidelines for the diagnosis and management of Barrett’s esophagus and early esophageal adenocarcinoma. J Gastroenterol Hepatol. 2015;30(5):804–20. https://doi.org/10.1111/jgh.12913.

    Article  PubMed  Google Scholar 

  6. Fitzgerald RC, di Pietro M, Ragunath K, Ang Y, Kang JY, Watson P, et al. British Society of Gastroenterology guidelines on the diagnosis and management of Barrett’s oesophagus. Gut. 2014;63(1):7–42. https://doi.org/10.1136/gutjnl-2013-305372.

    Article  PubMed  Google Scholar 

  7. Kuwano H, Nishimura Y, Oyama T, Kato H, Kitagawa Y, Kusano M, et al. Guidelines for diagnosis and treatment of carcinoma of the esophagus April 2012 edited by the Japan Esophageal Society. Esophagus. 2015;12:1–30. https://doi.org/10.1007/s10388-014-0465-1.

    Article  PubMed  Google Scholar 

  8. di Pietro M, Canto MI, Fitzgerald RC. Clinical endoscopic management of early adenocarcinoma and squamous cell carcinoma of the esophagus (screening, diagnosis and therapy). Gastroenterology. 2018;154(2):421–36. https://doi.org/10.1053/j.gastro.2017.07.041.

    Article  PubMed  Google Scholar 

  9. Ishihara R, Kanzaki H, Iishi H, Nagai K, Matsui F, Yamashina T, et al. Pink-color sign in esophageal squamous neoplasia, and speculation regarding the underlying mechanism. World J Gastroenterol. 2013;19(27):4300–8.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Inoue H, Honda T, Nagai K, Kawano T, Yoshino K, Takeshita K, et al. Ultra-high magnification endoscopic observation of carcinoma in situ of the esophagus. Digest Endosc. 1997;9(1):16–8. https://doi.org/10.1111/j.1443-1661.1997.tb00453.x.

    Article  Google Scholar 

  11. Oyama T, Inoue H, Arima M, Momma K, Omori T, Ishihara R, et al. Prediction of the invasion depth of superficial squamous cell carcinoma based on microvessel morphology: magnifying endoscopic classification of the Japan esophageal society. Esophagus. 2017;14(2):105–12. https://doi.org/10.1007/s10388-016-0527-7.

    Article  PubMed  Google Scholar 

  12. Arima M, Tada M, Arima H. Evaluation of microvascular patterns of superficial esophageal cancers by magnifying endoscopy. Esophagus. 2005;2(4):191–7. https://doi.org/10.1007/s10388-005-0060-6.

    Article  Google Scholar 

  13. Ogo T, Kawada K, Nakajima Y, Tokairin Y, Ito T, Kawano T. Comparative analysis of avascular areas in superficial esophageal squamous cell carcinomas using in vivo and ex vivo magnifying endoscopy. Endosc Int Open. 2017;5(10):E999–e1004. https://doi.org/10.1055/s-0043-117956.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Kim SJ, Kim GH, Lee MW, Jeon HK, Baek DH, Lee BE, et al. New magnifying endoscopic classification for superficial esophageal squamous cell carcinoma. World J Gastroenterol. 2017;23(24):4416–21.

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Rajvinder Singh .

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Singh, R., Zorron Cheng Tao Pu, L., Choi, K.C. (2021). Diagnosis of Superficial Esophageal Neoplasia: Classification. In: Chiu, P.W.Y., Sano, Y., Uedo, N., Singh, R. (eds) Endoscopy in Early Gastrointestinal Cancers, Volume 1. Springer, Singapore. https://doi.org/10.1007/978-981-10-6769-3_4

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  • DOI: https://doi.org/10.1007/978-981-10-6769-3_4

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  • Online ISBN: 978-981-10-6769-3

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