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Role and Regulation of Transcriptional Factors in Gastric Cancer

  • Nageswara Rao Reddy Neelapu
Chapter

Abstract

Gastric cancer is the second major cancer diagnosed worldwide. Cytokines, chemokines, metalloproteinases, prostaglandins, and reactive oxygen nitrogen species induce, amplify, and sustain inflammation (in the lining of the stomach) in the host. Signalling pathways like β-catenin, NF-κB, etc. bring about changes in the genetic material leading to diversification of genetic material. Genetic diversification in oncogenes and tumour suppressor genes leads to gastric cancer. Transcriptional factors’ role in apoptosis, cell cycle, cell proliferation, and metastasis (adhesion, invasion, migration, angiogenesis) is well known and established. The role and regulation of transcriptional factors in relation to gastric cancer was reviewed.

Keywords

Apoptosis Cell cycle Cell proliferation Gastric cancer Metastasis Transcription factors 

Notes

Acknowledgements

Nageswara Rao Reddy Neelapu thanks Gandhi Institute of Technology and Management (GITAM), Visakhapatnam, India. The author is thankful to Dr. Challa Surekha for the suggestions on manuscript. The author is also thankful to former Head of the Department Prof. I Bhaskar Reddy and present Head of the Department Prof. Malla Rama Rao for the support.

Conflict of Interests

Author declares no conflict of interest.

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© Springer Nature Singapore Pte Ltd 2017

Authors and Affiliations

  1. 1.Department of Biochemistry and Bioinformatics, School of Life Sciences, GITAM Institute of ScienceGandhi Institute of Technology and Management (GITAM)VisakhapatnamIndia

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