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Role of STAT3 in Pancreatic Cancer: A Target for Therapy

  • Waaqo B. Daddacha
  • Allyson E. Koyen
  • Ashley J. Schlafstein
  • David S. Yu
Chapter

Abstract

STAT3 is a member of the signal transducer and activator of transcription (STAT) family of proteins. Activation of the STAT3 signaling cascade results in the transcription of several pro-proliferative and anti-apoptotic proteins. STAT3 is also a potent modulator of the immune system, and its activation results in the suppression of the immune response. Dysregulation of STAT3 is implicated in the development and progression of a number of malignancies, including pancreatic ductal adenocarcinoma. Because of its involvement in tumorigenesis and the evasion of the immune response, STAT3 is emerging as a potential therapeutic target for pancreatic cancer, with several therapies currently under development.

Keywords

Pancreatic cancer STAT3 Immunotherapy 

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Copyright information

© Springer Nature Singapore Pte Ltd 2017

Authors and Affiliations

  • Waaqo B. Daddacha
    • 1
  • Allyson E. Koyen
    • 1
  • Ashley J. Schlafstein
    • 1
  • David S. Yu
    • 1
  1. 1.Department of Radiation OncologyEmory University School of MedicineAtlantaUSA

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