E2F1: Transcriptional Machinery in Colon Cancer

  • I. Vasavi
  • A. M. V. N. Prathyusha
  • Malothu Ramesh
  • K. Satish Kumar
  • B. Pratap Naidu
  • Pallaval Veera Bramhachari
  • N. M. Yugandhar
  • P. Rama Chandra Ganesh
Chapter

Abstract

E2F family of transcription factor acts as central modulator for important cellular events including cell cycle progression, apoptosis, and DNA damage response. E2F1 regulates G1/S-phase transition of cell cycle transactivating a variety of genes involved in chromosomal DNA replication, including its own promoter. E2F1 is regulated in a cell cycle-dependent manner, principally through its temporal association with pocket protein family member, retinoblastoma. Pocket proteins, in turn, regulated through phosphorylation by cyclin-dependent kinase (CDK). Different E2F family exhibits distinct cell cycle and apoptotic activities. This review focuses on E2F1 function and its putative role in colon cancer.

Keywords

E2F1 Colon cancer Retinoblastoma (RB) CDK 

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Copyright information

© Springer Nature Singapore Pte Ltd 2017

Authors and Affiliations

  • I. Vasavi
    • 1
  • A. M. V. N. Prathyusha
    • 2
  • Malothu Ramesh
    • 3
  • K. Satish Kumar
    • 4
  • B. Pratap Naidu
    • 2
  • Pallaval Veera Bramhachari
    • 2
  • N. M. Yugandhar
    • 5
  • P. Rama Chandra Ganesh
    • 6
  1. 1.Department of BiochemistryUniversity of LeicesterLeicesterUK
  2. 2.Department of BiotechnologyKrishna UniversityMachilipatnamIndia
  3. 3.Department of BiotechnologyJNTUKakinadaIndia
  4. 4.Department of ZoologyAdikavi Nannaya UniversityRajamundryIndia
  5. 5.Department of Chemical EngineeringAndhra UniversityVisakhapatnamIndia
  6. 6.Department of Marine Living ResourcesAndhra UniversityVisakhapatnamIndia

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