Abstract
In Chaps. 1 and 2, we introduced the physiological roles of mechanotransduction and the conceptual design of a mechanoreceptor. How does a real mechanoreceptor look like and what are its specific functions in physiology? In this chapter, we provide the introduction for the specialized mechanoreceptors in Drosophila melanogaster, including their distributions, tissue/cellular organizations, and physiological functions. As shown in this chapter, the mechanosensory transduction is a fundamental process in the daily life of a fly, for example, in walking, standing, flying, crawling, jumping, hearing, defecation, mating, etc. The broad involvement of mechanotransduction in fly’s life makes the fly mechanoreceptors great models to study the molecular, structural, and mechanical basis of mechanotransduction.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bechstedt S, Albert JT, Kreil DP, Muller-Reichert T, Gopfert MC, Howard J (2010) A doublecortin containing microtubule-associated protein is implicated in mechanotransduction in Drosophila sensory cilia. Nat Commun 1:11. https://doi.org/10.1038/ncomms1007
Bodmer R, Jan YN (1987) Morphological differentiation of the embryonic peripheral neurons in Drosophila. Roux Arch Dev Biol 196(2):69–77. https://doi.org/10.1007/BF00402027
Boekhoff-Falk G, Eberl DF (2014) The Drosophila auditory system. Wiley Interdiscip Rev Dev Biol 3(2):179–191. https://URL.org/10.1002/wdev.128
Bokolia NP, Mishra M (2015) Hearing molecules, mechanism and transportation: modeled in Drosophila melanogaster. Dev Neurobiol 75(2):109–130. https://doi.org/10.1002/dneu.22221
Cheng LE, Song W, Looger LL, Jan LY, Jan YN (2010) The role of the TRP channel NompC in Drosophila larval and adult locomotion. Neuron 67(3):373–380. https://doi.org/10.1016/j.neuron.2010.07.004
Demerec M (2008) Biology of drosophila. Cold Spring Harbor Laboratory Press, Woodbury
Dornan AJ, Goodwin SF (2008) Fly courtship song: triggering the light fantastic. Cell 133(2):210–212. https://doi.org/10.1016/j.cell.2008.04.008
Fayyazuddin A, Dickinson MH (1996) Haltere afferents provide direct, electrotonic input to a steering motor neuron in the blowfly. Calliphora J Neurosci 16(16):5225–5232
Fox JL, Daniel TL (2008) A neural basis for gyroscopic force measurement in the halteres of Holorusia. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 194(10):887–897. https://doi.org/10.1007/s00359-008-0361-z
Ghysen A, Dambly-Chaudiere C (1993) The specification of sensory neuron identity in Drosophila. BioEssays 15(5):293–298. https://doi.org/10.1002/bies.950150502
Gillespie PG, Walker RG (2001) Molecular basis of mechanosensory transduction. Nature 413(6852):194–202. https://doi.org/10.1038/35093011
Gorczyca David A, Younger S, Meltzer S, Kim Sung E, Cheng L, Song W et al (2014) Identification of Ppk26, a DEG/ENaC channel functioning with Ppk1 in a mutually dependent manner to guide locomotion behavior in drosophila. Cell Rep 9(4):1446–1458. http://dx.doi.org/10.1016/j.celrep.2014.10.034
Grueber WB, Jan LY, Jan YN (2002) Tiling of the Drosophila epidermis by multidendritic sensory neurons. Development 129(12):2867–2878
Guo Y, Wang Y, Wang Q, Wang Z (2014) The role of PPK26 in drosophila larval mechanical nociception. Cell Rep 9(4):1183–1190. doi:http://dx.doi.org/10.1016/j.celrep.2014.10.020
Hwang RY, Zhong L, Xu Y, Johnson T, Zhang F, Deisseroth K et al (2007) Nociceptive neurons protect Drosophila larvae from parasitoid wasps. Curr Biol 17(24):2105–2116. https://doi.org/10.1016/j.cub.2007.11.029
Jan YN, Jan LY (2010) Branching out: mechanisms of dendritic arborization. Nat Rev Neurosci 11(5):316–328. https://doi.org/10.1038/nrn2836
Kamikouchi A, Inagaki HK, Effertz T, Hendrich O, Fiala A, Gopfert MC et al (2009) The neural basis of Drosophila gravity-sensing and hearing. Nature 458(7235):165–171. http://www.nature.com/nature/journal/v458/n7235/suppinfo/nature07810_S1.html
Keil TA (1997) Functional morphology of insect mechanoreceptors. Microsc Res Tech 39(6):506–531. 10.1002/(SICI)1097-0029(19971215)39:6<506::AID-JEMT5>3.0.CO;2-B
Kim SE, Coste B, Chadha A, Cook B, Patapoutian A (2012) The role of Drosophila piezo in mechanical nociception. Nature 483(7388):209–212. https://doi.org/10.1038/nature10801
Li J, Zhang W, Guo Z, Wu S, Jan LY, Jan YN (2016) A defensive kicking behavior in response to mechanical stimuli mediated by Drosophila wing margin bristles. J Neurosci 36(44):11275–11282. https://doi.org/10.1523/JNEUROSCI.1416-16.2016
Lumpkin EA, Marshall KL, Nelson AM (2010) Review series: the cell biology of touch. J Cell Biol 191(2):237–248. https://doi.org/10.1083/jcb.201006074
Menon C, Brodie R, Clift S, Vincent JFV (2009) Concept design of strain sensors inspired by campaniform sensilla. Acta Astronaut 64(2–3):176–182. https://doi.org/10.1016/j.actaastro.2008.07.007
Robertson JL, Tsubouchi A, Tracey WD (2013) Larval defense against attack from parasitoid wasps requires nociceptive neurons. PLoS One 8(10):e78704. https://doi.org/10.1371/journal.pone.0078704
Singhania A, Grueber WB (2014) Development of the embryonic and larval peripheral nervous system of Drosophila. Wiley Interdiscip Rev Dev Biol 3(3):193–210. https://doi.org/10.1002/wdev.135
Suslak TJ, Watson S, Thompson KJ, Shenton FC, Bewick GS, Armstrong JD et al (2015) Piezo is essential for amiloride-sensitive stretch-activated mechanotransduction in larval Drosophila dorsal bipolar dendritic sensory neurons. PLoS One 10(7):e0130969. https://doi.org/10.1371/journal.pone.0130969
Tsubouchi A, Caldwell Jason C, Tracey WD (2012) Dendritic filopodia, ripped pocket, NOMPC, and NMDARs contribute to the sense of touch in drosophila Larvae. Curr Biol 22(22):2124–2134. doi:http://dx.doi.org/10.1016/j.cub.2012.09.019
von Philipsborn AC, Liu T, Yu JY, Masser C, Bidaye SS, Dickson BJ (2011) Neuronal control of Drosophila courtship song. Neuron 69(3):509–522. https://doi.org/10.1016/j.neuron.2011.01.011
Xiang Y, Yuan Q, Vogt N, Looger LL, Jan LY, Jan YN (2010) Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. Nature 468(7326):921–926. https://doi.org/10.1038/nature09576
Yan Z, Zhang W, He Y, Gorczyca D, Xiang Y, Cheng LE et al (2013) Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation. Nature 493(7431):221–225. https://doi.org/10.1038/nature11685
Yorozu S, Wong A, Fischer BJ, Dankert H, Kernan MJ, Kamikouchi A et al (2009) Distinct sensory representations of wind and near-field sound in the Drosophila brain. Nature 458(7235):201–205. http://www.nature.com/nature/journal/v458/n7235/suppinfo/nature07843_S1.html
Zhang W, Yan Z, Jan LY, Jan YN (2013) Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae. Proc Natl Acad Sci U S A 110(33):13612–13617. https://doi.org/10.1073/pnas.1312477110
Zhang W, Yan Z, Li B, Jan LY, Jan YN (2014) Identification of motor neurons and a mechanosensitive sensory neuron in the defecation circuitry of Drosophila larvae. elife 3. https://doi.org/10.7554/eLife.03293
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2017 The Author(s)
About this chapter
Cite this chapter
Liang, X., Sun, L., Liu, Z. (2017). Mechanoreceptors in Drosophila melanogaster . In: Mechanosensory Transduction in Drosophila Melanogaster. SpringerBriefs in Biochemistry and Molecular Biology. Springer, Singapore. https://doi.org/10.1007/978-981-10-6526-2_3
Download citation
DOI: https://doi.org/10.1007/978-981-10-6526-2_3
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-10-6525-5
Online ISBN: 978-981-10-6526-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)