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Colorectal Cancers Developed from Proximal and Distal Tumor Location Belong to the Distinct Genetic Entity and Show Different Oncologic Behavior

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Book cover Molecular Diagnosis and Targeting for Thoracic and Gastrointestinal Malignancy

Part of the book series: Current Human Cell Research and Applications ((CHCRA))

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Abstract

Colorectal cancer is now understood as a genetic disease.

Because of the importance of this highly prevalent disease, intense research efforts during the past two decades have focused on molecular processes to gain a better understanding of carcinogenesis. Since then, colorectal cancer has become a leading research model for the genetic basis of cancer. Attempt of molecular classification of colorectal cancer was made in order to offer precision medicine.

Colorectal cancer located either proximal or distal to the splenic flexure has been considered as belonging to different clinicopathological or physiological categories. Now, tumor location in colorectum is becoming an important surrogate marker to estimate prognosis and to determine the treatment decision including selection of chemotherapy agents for CRC.

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Authors and Affiliations

  1. Department Surgery, Amagasaki Central Hospital, 1-12-1 Shioe, Amagasaki, Hyogo, 661-0976, Japan

    Nagahide Matsubara

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  1. Nagahide Matsubara
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Correspondence to Nagahide Matsubara .

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Editors and Affiliations

  1. Department of Nanobio Drug Discovery, Kyoto University, Sakyo-ku, Kyoto, Japan

    Yutaka Shimada

  2. Department of Surgery, Jikei University School of Medicine, Minato-ku, Tokyo, Japan

    Katsuhiko Yanaga

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Matsubara, N. (2018). Colorectal Cancers Developed from Proximal and Distal Tumor Location Belong to the Distinct Genetic Entity and Show Different Oncologic Behavior. In: Shimada, Y., Yanaga, K. (eds) Molecular Diagnosis and Targeting for Thoracic and Gastrointestinal Malignancy. Current Human Cell Research and Applications. Springer, Singapore. https://doi.org/10.1007/978-981-10-6469-2_5

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  • DOI: https://doi.org/10.1007/978-981-10-6469-2_5

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-6468-5

  • Online ISBN: 978-981-10-6469-2

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