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Supramolecular Chemistry of Biomimetic Systems pp 85–108Cite as

Hemoglobin-Based Molecular Assembly

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Abstract

Development of protein-based molecular devices is an active area of research due to their broad applications in biotechnology, biorelated chemistry, bioelectronics, and biomedical engineering. Hemoglobin (Hb) is a physiologically important oxygen-transport metalloprotein present in the red blood cells. In this chapter, we present the recent development in fabrication and tailoring of a variety of hemoglobin protein shells via covalent layer-by-layer (LbL) assembly combined with template technique. Also, the developed strategy is effective and flexible, advantageous for avoiding denaturation of proteins. The as-fabricated Hb shells have better applications in drug delivery and controlled release, biosensors, biocatalysis, and bioreactors due to the enhancement of biological availability. In view of the carrying-oxygen function of Hb protein in blood, we particularly focus on the potential applications of hemoglobin-based nanoarchitectonic assemblies as artificial blood substitutes. These novel oxygen carriers exhibit advantages over traditional carriers and will greatly promote research on reliable and feasible artificial blood substitutes.

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Authors and Affiliations

  1. Northwest Institute of Nuclear Technology, Xi’an, Shaanxi, 710024, China

    Li Duan

  2. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China

    Yi Jia & Junbai Li

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  1. Li Duan
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  2. Yi Jia
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  3. Junbai Li
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Correspondence to Li Duan or Junbai Li .

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Editors and Affiliations

  1. Institute of Chemistry, Chinese Academy of Sciences, Beijing, China

    Junbai Li

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Duan, L., Jia, Y., Li, J. (2017). Hemoglobin-Based Molecular Assembly . In: Li, J. (eds) Supramolecular Chemistry of Biomimetic Systems. Springer, Singapore. https://doi.org/10.1007/978-981-10-6059-5_5

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