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Advantages of Self-assembled Supramolecular Polymers Toward Biological Applications

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Supramolecular Chemistry of Biomimetic Systems

Abstract

Supramolecular self-assembly provides a means of achieving “bottom-up” fabrication of nanoscale materials. Their mechanical properties and functionality arise from the assembly of relatively simple molecular building blocks. These materials have selective affinity to different interfaces, high capacity for interfacial adsorption, nanostructure, and spontaneous formation of unique nano-self-assemblies which exhibit remarkable simplicity and biocompatibility. Due to these attractive features, supramolecular nanostructures, particularly peptide-based, have recently been explored as effective nanomaterials in applications ranging from controlled release and drug delivery, nano-fabrication, skin care, biomineralization, sensing, antimicrobial materials, and tissue engineering. This range of applications is facilitated by the diverse primary sequences of the short peptides, which can be either biomimetic or de novo designed. Thus, their self-assembling mechanistic processes and nanostructures also vary enormously. This chapter highlights recent advances in studying self-assembled peptide systems, focusing on the formation of different nanostructures and their applications in diverse fields.

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Abbreviations

SAP:

Self-assembling peptide

CPTNs:

Cyclic peptide nanotubes

CPs:

Cyclic peptides

PAs:

Peptide amphiphiles

RGD:

Arginine–glycine–aspartic acid

CryoTEM:

Cryogenic transmission electron microscopy

CMC:

Critical micelle concentration

DOX:

Drug doxorubicin

CPP:

Cell penetrating peptide

GQDs:

Graphene quantum dots

FF:

Diphenylalanine

Fmoc:

Fluorenylmethoxycarbonyl

Boc-FF:

Tert-Butyloxycarbonyl-diphenylalnine

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Authors and Affiliations

  1. Department of Oral Biology, The Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel

    Michal Halperin-Sternfeld, Moumita Ghosh & Lihi Adler-Abramovich

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  1. Michal Halperin-Sternfeld
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  2. Moumita Ghosh
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  3. Lihi Adler-Abramovich
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Correspondence to Lihi Adler-Abramovich .

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  1. Institute of Chemistry, Chinese Academy of Sciences, Beijing, China

    Junbai Li

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Halperin-Sternfeld, M., Ghosh, M., Adler-Abramovich, L. (2017). Advantages of Self-assembled Supramolecular Polymers Toward Biological Applications. In: Li, J. (eds) Supramolecular Chemistry of Biomimetic Systems. Springer, Singapore. https://doi.org/10.1007/978-981-10-6059-5_2

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