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Supramolecular Chemistry of Biomimetic Systems pp 311–354Cite as

Polyoxometalates and Their Complexes Toward Biological Application

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Abstract

Polyoxometalates (POMs) are a type of inorganic polyanionic clusters bearing well-defined topologic architecture consisted of transition oxo-metalates. Due to their negatively charged features, various dimensions, acidity, and so forth, POMs also show specific functions in biological system. To understand the activity at molecular level, we start the discussion from the basic binding modes of POMs with biomolecules to the expression of the binding diversity on the crystallography, inhibition and hydrolysis of biomolecules. Moreover, the selective inhibition of POMs for biomolecules displays the potential roles in antitumor, antiviral, and antimicrobial activities. In the chapter, recent achievements concerning the applications of POMs on biological-related systems are summarized. The discussion involves the interaction of POMs with amino acids, peptides, and proteins, the co-crystallization of proteins with the help of POMs, the inhibitory effect of POMs on enzymes and some diseases, the mimetic enzyme functions of POMs for hydrolysis of peptides and proteins, the antiviral, antibacterial, and antitumoral activity of POMs, and their bio-imaging features.

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  1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, People’s Republic of China

    Lixin Wu & Jing Liang

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    Junbai Li

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Wu, L., Liang, J. (2017). Polyoxometalates and Their Complexes Toward Biological Application. In: Li, J. (eds) Supramolecular Chemistry of Biomimetic Systems. Springer, Singapore. https://doi.org/10.1007/978-981-10-6059-5_13

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