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Inflammasomes in the Gut Mucosal Homeostasis

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Book cover Regulation of Inflammatory Signaling in Health and Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1024))

Abstract

Inflammasomes are critical checkpoints in inflammation. The activation of inflammasome can cause a series of inflammatory responses including maturation of interleukin (IL)-1β and IL-18 and a specialized form of cell death called pyroptosis. Since its identification in the early 2000s, inflammasomes have been implicated to play multifaceted roles in varied pathological and physiological conditions, especially in the mucosal compartments including the gut. Maintaining gut mucosal homeostasis has always been a remarkable challenge for the host due to both the vast mucosal surface that is exposed to the outside and the enormous amount of local microbiota. To accomplish this challenge, the host mounts a constant dynamic low-grade inflammatory response (physiological inflammation) in coping with insults of microbes in the intestine. This book chapter aims to summarize the current knowledge of how inflammasomes contribute to gut mucosal homeostasis.

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Acknowledgments

Research in our lab is supported by grants from National Key Basic Research Programs (2015CB554302, 2014CB541905), Natural Science Foundation of China (31570895, 91429307, 31370892, 81761128012), as well as the Strategic Priority Research Program (XDPB0303) and the International Partnership Program of Chinese Academy of Sciences (153831KYSB20160009).

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  1. CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, 320 Yueyang Road, Life Science Research Building B-205, Shanghai, 200031, China

    Xiaomin Yao & Guangxun Meng

  2. University of Chinese Academy of Sciences, Beijing, 100039, China

    Xiaomin Yao

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  1. Xiaomin Yao
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  2. Guangxun Meng
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Correspondence to Guangxun Meng .

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  1. Faculty of Medical Laboratory Science, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Dakang Xu

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Yao, X., Meng, G. (2017). Inflammasomes in the Gut Mucosal Homeostasis. In: Xu, D. (eds) Regulation of Inflammatory Signaling in Health and Disease. Advances in Experimental Medicine and Biology, vol 1024. Springer, Singapore. https://doi.org/10.1007/978-981-10-5987-2_6

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