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Preeclampsia pp 99–112Cite as

Placental Adenosine Signaling in the Pathophysiology of Preeclampsia

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Part of the book series: Comprehensive Gynecology and Obstetrics ((CGO))

Abstract

Impairment in placental development and function is known to be associated with the pathophysiology of preeclampsia. However, placenta-specific molecular basis leading to preeclampsia remains to be fully understood. Adenosine, an endogenous nucleotide, is a signaling molecule that is induced under various pathological conditions including hypoxia, energy depletion, and inflammation and contributes to various diseases. Recent report form Iriyama et al. revealed that a local increase of adenosine in the placenta is sufficient to trigger key features of preeclampsia by using mouse models, and adenosine was identified as one of pathogenic factors for preeclampsia. This chapter is to summarize current progress and the significance of adenosine signaling in different disease states and to detail the findings of enhanced placental adenosine signaling in the pathophysiology of preeclampsia.

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Author information

Authors and Affiliations

  1. Faculty of Medicine, Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan

    Takayuki Iriyama M.D., Ph.D.

  2. Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, TX, USA

    Yang Xia M.D., Ph.D.

Authors
  1. Takayuki Iriyama M.D., Ph.D.
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  2. Yang Xia M.D., Ph.D.
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Correspondence to Takayuki Iriyama M.D., Ph.D. .

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Editors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan

    Shigeru Saito

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Iriyama, T., Xia, Y. (2018). Placental Adenosine Signaling in the Pathophysiology of Preeclampsia. In: Saito, S. (eds) Preeclampsia. Comprehensive Gynecology and Obstetrics. Springer, Singapore. https://doi.org/10.1007/978-981-10-5891-2_6

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  • DOI: https://doi.org/10.1007/978-981-10-5891-2_6

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  • Print ISBN: 978-981-10-5890-5

  • Online ISBN: 978-981-10-5891-2

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