Nanoparticles-Induced Oxidative Stress

  • Hainan Sun
  • Guizhen Yan
  • Hongyu ZhouEmail author
Part of the Nanomedicine and Nanotoxicology book series (NANOMED)


With the growing usage of nanoparticles (NPs) in industry, biomedicine, and daily life, an increasing chance for humans to be exposed to NPs has been issued. However, the basis of toxicity of most manufactured NPs is not fully understood. An important mechanism of nanotoxicity is reactive oxygen species (ROS) formation, which could cause oxidative stress, inflammation, and consequent cell death. NPs can interact with H2O or O2 in the physiological environment, resulting in the direct production of ROS, or affect the function of mitochondria and NADPH oxidase, resulting in the indirect production of ROS. ROS generation and oxidative stress were depicted by the hierarchical oxidative stress model. Critical determinants that can affect the generation of ROS, including NPs’ composition, size, shape, and surface chemistry, are briefly discussed in this review.


Oxidative stress Nanoparticles Nanotoxicity Reactive oxygen species Physicochemical properties 


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© Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Guangdong Key Laboratory of Environmental Pollution and Health, School of EnvironmentJinan UniversityGuangzhouChina
  2. 2.School of Chemistry and Chemical EngineeringShandong UniversityJinanChina
  3. 3.Lixia District People’s HospitalJinanChina

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