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Animal Models for Ischemic Stroke

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Book cover Translational Research in Stroke

Part of the book series: Translational Medicine Research ((TRAMERE))

Abstract

Developing reliable and reproducible animal model is of great importance in the therapeutic research of ischemic stroke. The location and volume of injury are varied in different animal models. Researchers choose different animal models according to the research purposes. In this chapter, we summarized the system of ischemic stroke models.

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Abbreviations

2-VO:

Two-vessel occlusion

4-VO:

Four-vessel occlusion

CBF:

Cerebral blood flow

CCA:

Common carotid artery

ECA:

External carotid artery

EPCs:

Endothelial progenitor cells

ICA:

Internal carotid artery

MCAO:

Middle cerebral artery occlusion

mNSS:

Modified neurological severity score

PPA:

Pterygopalatine artery

rt-PA:

Recombinant tissue plasminogen activator

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Authors and Affiliations

  1. Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai, 200030, China

    Liping Wang, Chuan Qin & Guo-Yuan Yang

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  1. Liping Wang
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  2. Chuan Qin
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  3. Guo-Yuan Yang
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Correspondence to Guo-Yuan Yang .

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Editors and Affiliations

  1. Department of Neurology & Neurosurgery, Cedars-Sinai Medical Center, Advanced Health Sciences Pavilion, Los Angeles, California, USA

    Paul A. Lapchak

  2. Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

    Guo-Yuan Yang

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Wang, L., Qin, C., Yang, GY. (2017). Animal Models for Ischemic Stroke. In: Lapchak, P., Yang, GY. (eds) Translational Research in Stroke. Translational Medicine Research. Springer, Singapore. https://doi.org/10.1007/978-981-10-5804-2_16

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